| 摘要: |
| 目的 研究不同前列腺癌超声造影参数与ki-67蛋白表达的相关性研究。
方法 收集经直肠前列腺穿刺活检确诊为前列腺癌的95例男性患者，术前行超声造影检查，用QLAB软件分析病灶时间—强度曲线，记录定量参数。取患者异常增强区域组织，采用免疫组化检测ki-67蛋白的表达情况，分为阴性组、低表达组、高表达组，分析超声造影参数与ki-67蛋白表达的相关性，利用ROC 曲线评价超声造影参数对ki-67阴阳性表达的准确性。结果 AUC、 PI、HT、MTT、WIS 5个超声造影参数在不同ki-67蛋白表达分级组间比较差异有统计学意义（P < 0.05），且呈正相关性，相关系数（r值）分别为0.657、0.537、0.503、0.407、0.023，根据ROC曲线显示造影参数AUC、PI、HT对于ki-67表达水平有较高的诊断价值，当诊断界值为>479.44、>7.71、>49.48,曲线下面积为0.848、0.793、0.752，其中AUC具有较高的特异度及灵敏度，分别为83.64%、73.24%。结论 超声造影时间-强度曲线中AUC、PI、HT与ki-67蛋白表达高低具有相关性，这些参数可以为无创的评估前列腺癌的肿瘤细胞增殖程度及肿瘤血管生成提供一定的依据，可以作为预测肿瘤恶性程度及预后的影像学指标。 |
| 关键词: 超声检查、前列腺癌、超声造影参数、ki-67蛋白 |
| DOI： |
| 投稿时间：2019-08-30修订日期：2020-03-31 |
| 基金项目:超声造影在前列腺癌生物学行为中的研究 |
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| Correlation between contrast-enhanced ultrasound (CEUS) parameters and ki-67 protein expression in prostate cancer |
| Liu hui,Hong hua |
| (Inner Mongolia autonomous region people's hospital;Inner Mongolia autonomous region people''s hospital) |
| Abstract: |
| To study the correlation between different ceus parameters and ki-67 protein expression in prostate cancer. Methods A total of 95 male patients diagnosed with prostate cancer by rectal biopsy were collected, and preoperative contrast-enhanced ultrasound was performed. The time-intensity curve of the lesion was analyzed by QLAB software, and quantitative parameters were recorded.The tissues of patients with abnormal enhancement were selected, and the expression of ki-67 protein was detected by immunohistochemistry. The expression of ki-67 protein was divided into negative group, low expression group and high expression group. The correlation between ceus parameters and expression of ki-67 protein was analyzed, and the accuracy of ceus parameters for negative and positive expression of ki-67 was evaluated by using ROC curve. Results AUC, PI, HT, determined by MTT, WIS five contrast-enhanced ultrasound parameters in different ki - 67 protein expression classification comparative differences between groups was statistically significant (P < 0.05), and there was a positive correlation, the correlation coefficient (r value) were 0.657, 0.537, 0.503, 0.407, 0.023, according to the ROC curve display imaging parameter AUC, PI, HT for ki - 67 expression level had higher diagnostic value,When the diagnostic thresholds are >479.44, >7.71, >49.48, the area under the curve is 0.848, 0.793, 0.752, and the AUC has high specificity and sensitivity, respectively 83.64% and 73.24%.Conclusion The expression levels of AUC, PI, HT and ki-67 proteins in the time-intensity curve of ceus are correlated. These parameters can provide a certain basis for the noninvasive evaluation of the proliferation degree of tumor cells in prostate cancer, and can be used as imaging indicators to predict the degree of tumor malignancy. |
| Key words: Ultrasound Prostate cancer Contrast-enhanced ultrasound parameters ki-67 protein |
