| 摘要: |
| 基因转染技术的高速发展,不仅革新了生物学和医学的许多基本问题的研究,也推动了诊断和治疗的进步。基因作为核酸类生物活性大分子,体内极易被降解,因此递送基因的载体尤为重要。超声靶向微泡破坏技术(UTMD)利用超声波和微泡之间的相互作用及其产生的生物学效应,使微泡携基因从而进行基因转染,并且能与多种载体联合应用,可为多种疾病的治疗提供有效的手段。本文就超声靶向微泡破坏技术介导基因转染的最新研究进展进行综述。 |
| 关键词: 超声靶向微泡破坏技术 基因转染 微泡 载体 |
| DOI： |
| 投稿时间：2019-09-01修订日期：2019-09-02 |
| 基金项目:国家自然科学基金(81801712) |
|
| Research progress of ultrasound-targeted microbubble destruction-mediated gene transfection |
| zhangyue,zhouhouren,xinying,lishihui,liuxiaoqi,liuzhijun |
| (SHENGJING HOSPITAL OF CHINA MEDICAL UNIVERSITY) |
| Abstract: |
| The rapid development of gene transfection technology has not only revolutionized the research of many basic problems in biology and medicine, but also promoted the progress of diagnosis and treatment. As a biologically active macromolecule of nucleic acids, the gene is easily degraded in the body, so the carrier for gene delivery is particularly important. Ultrasound-targeted microbubble destruction technology (UTMD) utilizes the interaction between ultrasound and microbubbles and the biological effects it produces to enable microbubbles to carry genes for gene transfection and can be used in combination with a variety of vectors. The treatment of a variety of diseases provides an effective means. This article reviews the recent advances in ultrasound-targeted microbubble destruction-mediated gene transfection. |
| Key words: ultrasound-targeted microbubble destruction gene transfection microbubble carrier |
