| 摘要: |
| 目的 探讨剪切波弹性成像(SWE)技术评估非酒精性脂肪肝病(NAFLD)大鼠肝纤维化程度的应用价值。
方法 SD大鼠88只，随机分为对照组(40只)和实验组(44只),对照组给予普通饲喂，实验组通过不同饮食建立不同纤维化分期的NAFLD大鼠模型，分别于第 1、2、3、8、12周末行大鼠肝脏SWE检查及病理分析。
结果 所有大鼠肝脏Emean与肝纤维化程度呈显著正相关(r=0.82，P＜0.001)。不同纤维化分期的Emean组间差异有统计学意义(F=25.5，P＜0.05)；除了F1和F2组之间Emean没有显着差异(P＞0.05)，其余任意两组之间的肝 Emean 比较差异均有统计学意义(均P＜0.05)。SWE诊断肝纤维化≥F1、≥F2、≥F3、＝F4的截值分别为6.3、7.4、8.6、9.7kPa，曲线下面积(AUC)分别为0.87、0.89、0.93、0.98，敏感性和特异性分别为83.3%、93.3%、100%、100%和85.5％、83.1%、91.3%、92.7%。
结论 SWE技术可有效评估NAFLD的肝纤维化程度。 |
| 关键词: 剪切波弹性成像 非酒精性脂肪肝病 肝纤维化 |
| DOI： |
| 投稿时间：2019-09-10修订日期：2019-10-10 |
| 基金项目:福建省临床重点专科建设项目资助 |
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| Shear wave elastography for assessment of hepatic fibrosis in rat models of nonalcoholic fatty liver disease |
| Zhou Qin,Lyu Guo-rong,Guo Hanxin,Li Jingyun,Zhang Shaobo,Chen Yongjian |
| (Department of Ultrasound,the Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian PR China) |
| Abstract: |
| Objective To explore the value of shear wave elastography (SWE) in the assessment of hepatic fibrosis in rat models of nonalcoholicai fatty liver disease (NAFLD). Methods SD rats were randomly divided into control group (40) and experimental group (44). Control group was fed a normal diet.Experimental group models with various stages of hepatic fibrosis were created and imaged using SWE.
The explanted livers were subjected to histopathologic evaluation. Results There were significant positive correlations between Emean and hepatic fibrosis stages(r=0.838,P＜0.001) in all animals.Emean differed significantly according to fibrosis stage(F=25.5，P＜0.05).A significant difference in Emean were noted between every two fibrotic groups（P＜0.05 for all）, with the exception of the difference between F1 and F2 groups (P ＞0.05). For classifying fibrosis stage,corresponding optimal SWE cutoff values were 6.3,7.4,8.6 and 9.7 kPa,and the area under the ROC curve(AUC) were 0.87,0.89,0.93,0.98,with a sensitivity of 83.3%,93.3%,100%,100% and a specifificity of 85.5％,83.1%,91.3%,92.7%. Conclusion Shear wave elastography is a promising method for staging the degree of hepatic fibrosis with NAFLD. |
| Key words: shear wave elastography nonalcoholicai fatty liver disease hepatic fibrosis |
