Objective To investigate the clinical manifestations and ultrasound features of mesenchymal hamartoma of liver. Methods This study retrospectively analyzed the clinical features and ultrasound characteristics of 7 patients of MHL, whose diagnosis were confirmed by surgery or liver biopsy from January 2011 to December 2018. Results Among 7 patients of MHL, the male-to-female ratio was 3:4,with the mean age range from 8 months to 24 years. All patients had single lesion, most lesions located in the right lobe, only 1 case located in the left lobe. The diameter of the lesions were 12-16cm.Septa-cystic(2 cases)、solid-cystic(4 cases) and echogenic(1 case) lesions were shown by sonography, the border and shape of the lesions were clearly defined in all cases. Color Doppler flow imaging showed none blood flow signal in septa cystic lesions, whereas the solid part of the solid-cystic lesions and echogenic lesion showed line blood flow signal. Conclusion The age of onset for MHL seems less than 2 years. Most MHL are single large lesions in the right lobe of liver, ultrasound show a septa-cystic or solid-cystic lesion with clear border and regular shape.