The most common site of thrombosis in patients with atrial fibrillation is the left auricle. Some clinical practices have confirmed that percutaneous left auricular occlusion has become an effective treatment method to prevent stroke in nonvalvula atrial fibrillation patients. Transesophageal echocardiography， transthoracic echocardiography and other echocardiography techniques have played important role in preoperative examination, intraoperative guidance and postoperative evaluation. This paper reviews the application progress of echocardiography in percutaneous left auricular occlusion.