Purpose: The aim of this study was to evaluate the correlation between HEAD_-US-Cscore and the clinical function score in adult hemophiliacs joints.Methods: in this study, the knee, elbow and ankle of 40 adult hemophilia patients were evaluated by Hemophilic Early Arthropathy Detection with UltraSound in China( HEAD_-US-C ),the joint function was evaluated by Hemophilia Joint Health Scores 2.1(HJHS 2.1) and The Functional Independence Score for Haemophilia (FISH).Results: We evaluated 240 joints in 40 patients,HEAD_-US-C score was 22.50(8.00,30.50), HJHS score was 31.50(15.50,46.75), and FISH score was 27.00(21.50,32.00). HEAD-US-C score, HJHS score and FISH score in mild patients were significantly different from moderate patients and severe patients (P<0.001). There was no statistically significant difference between HEAD_-US-C score, HJHS score and FISH score between patients with hemophilia A and B (r=0.844, r=-0.825, P<0.001).The HEAD_-US-C scores of knee, elbow and ankle were significantly correlated with HJHS score and FISH score (P<0.001).Conclusion: HEAD_-US-C score has a good correlation with HJHS score and FISH score, and ultrasound can provide more objective evaluation of joint injury.