| 摘要: |
| 目的 利用FibroTouch技术，评价2型糖尿病肾病（DN）患者肝脏脂肪变性和肝脏纤维化的程度及二者的相关性。方法 选取2型糖尿病肾病患者90例。根据肾小球滤过率（eGFR）将其分为三组，eGFR≥90ml?min-1(1.73m2)-1为A组(30例)，60ml?min-1?(1.73m2)-1≤eGFR＜90ml?min-1?(1.73m2)-1为B组（30例），eGFR＜60 ml?min-1?(1.73m2)-1为C组（30例），同时选取30名健康志愿者为对照组。应用FibroTouch技术获得肝脏脂肪衰减值（db/m）和肝脏硬度值（Kpa）。结果 各组肝脏脂肪衰减值和肝脏硬度值比较，A、B、C组均明显高于对照组（P均＜0.05），B、C组均高于A组（P均＜0.05），C组高于B组（P＜0.05）；肝脏脂肪衰减值和肝脏硬度值呈正相关关系（r=0.733，P＜0.01）。结论 应用FibroTouch技术可以准确、无创地评价DN患者的肝脏脂肪变性和纤维化程度，具有重要的临床意义。 |
| 关键词: 脂肪肝 肝纤维化 糖尿病肾病 超声检查 FibroTouch |
| DOI： |
| 投稿时间：2019-12-03修订日期：2020-09-01 |
| 基金项目: |
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| Evaluation of liver steatosis and fibrosis in patients with Type 2 diabetic nephropathy and their correlation by FibroTouch technique |
| LiuLu,Zhang Yuhong,Su Benli |
| (The Second Hospital of Dalian Medical University) |
| Abstract: |
| Objective To evaluate the degree of hepatic fibrosis and steatosis and their correlation in patients with type 2 diabetic nephropathy (DN) by FibroTouch technique. Methods Ninety patients with type 2 diabetic nephropathy were enrolled and divided into three groups according to the level of estimate glomerular filtration rate (eGFR): eGFR≥90ml ?min-1 (1.73m2)-1 as group A (n=30); 60ml ?min-1 (1.73m2)-1≤ eGFR<90ml ?min-1 (1.73m2)-1 as group B (n=30) and eGFR<60 ml ?min-1 (1.73m2)-1 as group C (n=30). Meanwhile, 30 healthy volunteers were enrolled as normal control group. The fat attenuation value (db/m) and the liver stiffness value (Kpa) were obtained by FibroTouch technique. Results The fat attenuation values and the liver stiffness values of the group A, B and C were significantly higher than that of the control group (all P<0.05). The fat attenuation value (db/m) and the liver stiffness value (Kpa) of the group B and C were higher than that of the group A (all P<0.05).And The fat attenuation value (db/m) and the liver stiffness value (Kpa) of the group C was higher than that of the group B (P<0.05). The fat attenuation value was positively correlated wirh the liver stiffness value(r=0.733,P<0.01). Conclusion The degree of hepatic steatosis and fibrosis of DN patients can be evaluated accurately and non-invasively by FibroTouch technique with an important clinical value. |
| Key words: Fatty liver Hepatic fibrosis Diabetic Nephropathy Supersonic inspection FibroTouch |
