Objective To explore the correlation between the level of serum uric acid and the content of intra-abdominal fat and other clinical indexes in the middle-aged and elderly women. Methods A total of 256 middle-aged and elderly women were selected for physical, blood, and ultrasound examinations to obtain parameters such as age, height, body weight, waist circumference, hip circumference, blood biochemical indicators and left perirenal fat sac area.According to the presence or absence of abnormal SUA levels (Female＞360 μmol / L), they were divided into HUA group and non-HUA group, and the differences in the above parameters were compared between the two groups. Binary Logistic regression was used to analyze independent risk factors affecting the prevalence of hyperuricemia (HUA). Results There were 24 cases in the HUA group and 323 cases in the non-HUA group. There was a statistically significant difference in TG, left renal renal fat capsule area and systolic blood pressure between the two groups (all P<0.05); the other parameters were not statistically different. Binary logistic regression analysis showed that the occurrence of HUA was independently related to hip circumference, triglyceride, serum creatinine level, and area of left perirenal fat sac (OR = 1.078, 2.079, 1.104, 1.384, all P<0.05). Conclusion The increase of hip circumference，left perirenal fat sac area，triglyceride and serum creatinine levels may be independent risk factors for HUA in middle-aged and elderly women.