Objective:To investigate the diagnostic value of gastrointestinal contrast ultrasound with or without acoustic pulse radiation force imaging (ARFI) technology for common benign and malignant lesions of the gastric wall.Methods:The clinical data of 67 patients with thickened gastric wall treated in the hospital from April 2017 to April 2019 were retrospectively analyzed. They were divided into benign group (49 cases) and malignant group (18 cases) based on the results of pathological biopsy. Both groups of patients underwent gastrointestinal ultrasound and ARFI. Contrast-enhanced ultrasound indicators (stomach emptying time (t_1/2), gastric antrum motility index (MI)) and ARFI (mean shear wave velocity (SWV)) of the two groups of patients were recorded. (ROC) curve comparison of the above indicators for the diagnosis of common benign and malignant lesions of the gastric wall.Results:The t_1/2 and SWV of benign patients were (73.04±18.65) min and (1.38±0.26) m/s, respectively, which were lower than those of malignant patients (84.20±21.44) min and (2.41±0.74) m/s. The MI was (63.37±21.05) greater than that of patients in the malignant group (52.22±16.55), and the difference was statistically significant (P<0.05).The ROC curve shows that t_1/2, MI, and SWV have certain diagnostic value for common benign and malignant lesions of the gastric wall, and the three combined (AUC=0.946, P<0.05) have higher diagnostic value.Conclusion:The value of gastrointestinal ultrasonography combined with ARFI in the diagnosis of common benign and malignant lesions of the gastric wall is superior to that of simple gastrointestinal ultrasound.