| 摘要: |
| 目的 探讨声触诊组织成像定量（VTIQ）技术在评估大鼠急性肝衰竭及预防性用药效果中的应用价值。方法 将24只雄性SD大鼠随机分为对照组，模型组和治疗组，每组8只。治疗组予以美常安（100mg·kg-1·d-1 ）稀释后灌胃治疗，对照组及模型组每天给予同等量温生理盐水灌胃，共8天；模型组及治疗组于实验第6、7天注射TAA（200mg·kg-1 ·d-1），共两次。分别在造模前后测量三组大鼠肝脏的剪切波速度（SWV，单位m/s），比较三组SWV值是否存在差异，以病理结果为金标准评估肝脏损伤的程度。结果 造模前对照组、模型组及治疗组SWVmean（m/s）分别为2.43±0.57、2.61±0.42和2.71±0.49，差异无统计学意义（P＞0.05）。造模后对照组、模型组及治疗组SWVmean（m/s）分别为2.50±0.71、3.56±0.48和3.06±0.27；模型组SWV较对照组升高，差异有统计学意义（P＜0.05）；预测ALF的截断值为2.83m/s，ROC曲线下面积、敏感度和特异度分别为0.938、100%和75.00%；治疗组SWV低于模型组，差异有统计学意义（P＜0.05）。结论 VTIQ技术在预测急性肝衰竭及评估预防性用药效果的中具有潜在应用价值。 |
| 关键词: 急性肝衰竭 超声检查 声触诊组织成像定量 硫代乙酰胺 美常安 |
| DOI： |
| 投稿时间：2020-01-04修订日期：2020-09-16 |
| 基金项目:山西省科技厅重点研发计划项目（201703D421029） |
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| Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication |
| duyang,wangxinghua |
| (Department of Ultrasonography, the Second Hospital of Shanxi Medical University) |
| Abstract: |
| Objective To investigate the clinical application value of virtual touch tissue imaging quantification (VTIQ) technique in detecting acute liver failure（ALF） and evaluating the effect of preventive medication in rats.Materials and Methods Twenty-four male SD rats were randomly divided into the control group,the model group,and the treatment group,with eight rats in each group. The treatment group was treated by gavage with Medilac-S(100mg·kg-1·d-1) after?dilution, while the control group and the model group were treated with the same volume of warm normal saline for eight days.On the 6th and 7th day of the experiment, the model group and the treatment group were intraperitoneally injected with TAA (200mg·kg-1·d-1). The shear wave velocity(SWV, m/s) in the liver were measured and compared among three groups of rats before and after the establishment of the model，using pathological result as the gold standard to evaluate the degree of liver injury. Results Before modeling, the SWVmean(m/s) of control group, model group and treatment group were 2.43±0.57,2.61±0.42 and 2.71±0.49,the difference had no statistical significance(P＞0.05).After modeling, the SWVmean(m/s) of control group, model group and treatment group were 2.50±0.71,3.56±0.48 and 3.06±0.27.The SWVmean in the model group was higher than that in the control group,the difference had statistical significance(P＜0.05).With cut-off value of 2.83m/s, the AUC, sensitivity and specificity were 0.938, 100% and 75.00% in predicting ALF. The SWVmean in the treatment group was lower than that in the model group,the difference had statistical significance(P＜0.05).Conclusion The VTIQ technique has potential application value in predicting acute liver failure and evaluating the effect of preventive medication. |
| Key words: Acute liver failure Ultrasonography Virtual touch tissue imaging quantification Thioacetamide Medilac-S |
