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超声对甲状腺微小乳头状癌腺外侵犯假阳性、假阴性的相关因素分析 |
王娴,谌业荣,张国梁,张津,张衡,钱晓芹,胡曙东 |
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(江苏大学附属人民医院超声科;江苏大学附属人民医院影像科;江苏大学附属人民医院普外科;江南大学附属医院影像科) |
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摘要: |
【摘要】目的:探讨甲状腺微小乳头状癌的超声特征与甲状腺外侵犯假阴性(FN,false negative)、假阳性(FP,false positive)的相关因素。材料和方法:收集 2016年1月份至 2019年1月份术前行超声检查且病理最终确诊为甲状腺微小乳头状癌的326例患者(472枚结节),计算超声评估甲状腺微小乳头状癌的甲状腺外侵犯的敏感性、特异性、阳性预测值(positive predictive value, PPV)、阴性预测值(negative predictive value, NPV)、准确度,对上述结果进行χ2检验统计学处理,并且分析其超声待征与FN、FP的相关因素。结果:超声评估甲状腺微小乳头状癌的甲状腺外侵犯敏感性、特异性、PPV、NPV和准确度分别为51.7%、86.7%、62.4%、80.8%和73.6%,单变量分析结果显示肿瘤直径≤5mm,纵横径比≥1,与气管不相邻、单侧叶病变与FN呈相关性(P<0.05);多变量分析结果显示,与气管不相邻和单侧叶病变是FN的独立危险因素(OR=4.916、7.237,P<0.05)。单变量分析结果显示肿瘤直径≤5mm与FP呈相关性(P<0.05)。结论:甲状腺微小乳头状癌原发病变超声特点(大小、形状、部位)是影响甲状腺微小乳头状癌的甲状腺外侵犯诊断结果的重要因素。 |
关键词: 甲状腺肿瘤 癌,乳头状 甲状腺外侵犯 超声检查 假阴性 假阳性 |
DOI: |
投稿时间:2020-01-07修订日期:2020-01-19 |
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目) |
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Ultrasonographic features associated with false-negative and false-positiveresults of extrathyroidal extensions in papillary thyroidmicrocarcinomaWang xian1 Chen yerong2? Zhang guoliang3? Zhang jin1? Zhang heng2 Qian xiaoqin1 Hu shudong4,* |
wang xian,Chen ye rong,Zhang guo liang,Zhang jin,zhang heng,qian xiao qin,hu shu dong |
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Abstract: |
【Abstract】 Objective:To assess the ultrasonographic features affect false
negative,falsepositiveofextrathyroid extension(ETE) evaluation on preoperative ultrasonography in papillary thyroid microcarcinoma(PTMC) .Methods:Between January 2016andJanuary 2019,326consecutive patients (472nodules) underwent surgery for pathologically confirmed PTMCs. We analyzed the medical records of all patients with PTC with preoperative USscan to calculate the sensitivity, specificity, positive predictive value (PPV), negative predictive value(NPV)and accuracy of the presence of ETE. The diagnostic performances of US in the evaluation of ETE using the χ2 test.The factors associated with false-negative(FN) and false-positive(FP) results for ETE were analyzed.Results: The sensitivity, specificity, PPV, NPV, and accuracy for predicting ETE according to sonographic criteria were 51.7%,86.7%,62.4%,80.8%和73.6%, respectively.In univariate analysis showed that diameter of tumor ≤5mm, taller than wider shape, vicinity to the trachea (non-adjacent) and non-bilaterality were associated with FN(P<0.05);multiple logistic regression analysis showed that vicinity to the trachea (non-adjacent) ,non-bilaterality is independent risk factor for FN(OR=4.916、7.237,P<0.05).In univariate analysis showed that diameter of tumor ≤5mm is associated with FP(P<0.05). |
Key words: Thyroid neoplasm Carcinoma, papillary extrathyroidal extension Ultrasonography falsenegative false positive |
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