Objective: To study the early diagnosis value of lung ultrasound for Transient tachypnea of the newborn(TTN).Methods: 80 cases of neonates with dyspnea admitted to neonatology department of Huadu District People Hospital of Guangzhou from April 2019 to December 2019 were selected. According to the clinical diagnosis results, the neonates were divided into TTN group (n=57) and Respiratory distress syndrome (RDS) group (n=23).Results: The proportions of abnormal pleural line, white lung sign, double lung point, AIS and pulmonary consolidation compared between TTN group and RDS group with no statistically significant differences(P>0.05).The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of lung ultrasound in early diagnosis of TTN were respectively94.74%, 95.65%, 98.18%, 88.00% and 95.00% .The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of X-ray in early diagnosis of TTN were respectively 84.21%, 82.61%, 92.31%, 67.86%, 83.75%, the sensitivity , specificity, positive predictive value, negative predictive value of lung ultrasound in early diagnosis of TTN were higher than X-ray, but the difference was no statistically significant (P>0.05),the accuracy of lung ultrasound in early diagnosis of TTN was obviously higher than X-ray, compared with statistically significant differences between both(P<0.05).Conclusion:Early diagnosis value of lung ultrasound for neonatal TTN is significant,it is worthy of clinical application.