Objective To investigate the clinical application of 4D-RV-Volume in the assessment of right ventricular systolic function in patients with essential hypertension. Methods 84 patients with essential hypertension were divided into normal LVMI group (44 cases) and high LVMI group (40 cases) according to different left ventricular mass index (LVMI), 45 health examiner were chosen as the control group, Left ventricular end diastolic diameter (LVIDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), tricuspid annulus systolic displacement (TAPSE), ratio of early to late peak velocity (E / a), pulmonary artery systolic pressure (PASP) and right ventricular Tei index were recorded. 4D-RV-Volume technique was used to obtain the parameters of right ventricular end diastolic volume (RVEDV), right ventricular end systolic volume (RVESV), right ventricular ejection fraction (RVEF), right ventricular free wall longitudinal strain rate (RVFLS), interventricular septal longitudinal strain rate (RVSLS), area change fraction (RVFAC). Results LVIDD, LVESD, LVPWT, IVST, RVEDV, RVESV of the high LVMI group were higher than those of the control group (P < 0.05), LVEF was lower than that of the control group (P < 0.05), TAPSE of the high LVMI group was higher than that of the control group and the normal LVMI group (P < 0.05), E / A, RVFLS, RVFAC, and RVEF of the control group, the normal LVMI group and the high LVMI group decreased (P < 0.05), PASP and Tei index increased (P < 0.05). RVSLS was lower than that of the normal group and the control group (P < 0.05). RVEF was negatively correlated with Tei index and PASP (r = -0.513, - 0.470, P < 0.05), and positively correlated with TAPSE (r = 0.607, P < 0.05). RVEDV, RVESV, and RVEF in the right ventricle showed good coherence by 4D-RV-Volume technique . Conclusion 4D-RV-Volume technique can be used to quantitatively analyze the structure and function of right ventricle in patients with essential hypertension, and it can provide evidence for the evaluation of hypertension and the prevention and treatment of cardiovascular complications.