?Abstract Purpose To explore the clinical significance of contrast enhancement characteristics of contrast-enhanced ultrasound in the diagnosis of focal peripheral lung lesions. Methods 116 peripheral pulmonary lesions were retrospectively analyzed, including 62 benign lesions and 54 malignant lesions. Lesions ultrasonic imaging enhancement phase (Δ T < 2.5s for early enhancement, Δ T≥ 2.5s for late enhancement ) and the enhancement patterns were recorded, and the difference between benign and malignant lesion group was compared, and then the diagnosis efficiency was analyzed. Results In the benign lesion group, early enhancement was dominant, while in the malignant lesion group, late enhancement was dominant, accounting for 82.3% and 64.8%, respectively, there was a statistically significant difference between benign and malignant lesions in the enhancement phase (P<0.05). In enhancement mode, the benign lesion group was characterized by Rapid basement dendrite enhancement, while the malignant lesion group was characterized by Dot chip enhancement, the difference between benign and malignant lesions was statistically significant (P<0.05). Early enhancement and Rapid basement dendrite enhancement were used as indicators to judge benign lesions, with sensitivity, specificity and accuracy (82.3%, 22.6%), (66.7%, 94.4%) and (75.0%, 56.0%), respectively. Late enhancement and Dot chip enhancement were used as the indicators of malignant lesions, respectively, and their sensitivity, specificity and accuracy were (64.8%, 68.5%), (85.5%, 62.9%), (75.9%, 65.5%), respectively. Conclusion contrast-enhanced ultrasound is of high clinical value in the differential diagnosis of focal benign and malignant lesions of peripheral lung.