| 摘要: |
| 目的:研究甲状腺乳头状癌合并桥本氏甲状腺炎的多模态超声成像（灰阶超声、弹性成像及超声造影）特征及其侵袭性、BRAFV600E 突变特点。
方法：158名术后证实为PTC的患者分为HT组和非HT组，比较两组的灰阶超声、超声造影、弹性成像以及侵袭性、BRAFV600E 突变的差异性。
结果：两组的超声特征表现（病灶的边界、纵横比、微小癌、微钙化、病灶数目、颈部淋巴结转移）、超声造影、弹性成像比较差异均无统计学意义。PTC合并HT组中女性比单纯的PTC组更多，差异有统计学意义（P＜0.05）。PTC合并HT组的甲状腺外侵袭率及BRAFV600E突变率均低于单纯PTC组，两者差异均有统计学意义（P＜0.05）。当BRAFV600E突变阳性时，PTC合并HT组的甲状腺外侵袭率仍低于单纯PTC组，且差异有统计学意义（P＜0.05）。
结论：PTC合并HT时，HT在一定程度上降低了病变的侵袭性，而当PTC中发生BRAFV600E基因突变时，HT的存在也可能阻碍了PTC的发展或侵袭性。 |
| 关键词: 甲状腺乳头状癌，桥本氏甲状腺炎，多模态超声成像，BRAFV600E |
| DOI： |
| 投稿时间：2020-01-30修订日期：2020-02-24 |
| 基金项目: |
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| The study of multimodality ultrasonographic features, aggressiveness and BRAFV600E mutation in papillary thyroid carcinoma with Hashimoto''s thyroiditis |
| chen ni,huang xiao ling,liu li ping,li mao ping,peng xiao qiong |
| (the First Affiliated Hospital, Chongqing Medical University) |
| Abstract: |
| Objective :To investigate the characteristics of multiodality ultrasound imaging (gray-scale ultrasound, elastography and contrast enhanced ultrasound),invasiveness and BRAFV600E mutation in papillary thyroid carcinoma with Hashimoto''s thyroiditis. Methods: 158 patients with positive PTC were divided into HT group and non-HT Group.The differences of gray-scale ultrasound(border, aspect ratio, microcarcinoma, microcalcification, number of lesions, cervical lymph node metastasis),elastography,contrast-enhanced ultrasound, invasiveness and BRAFV600E mutation between the two groups were compared. Results: There was no significant difference between the two groups in gray-scale ultrasound, elastography and contrast-enhanced ultrasound. There were more female patients in HT group than those in non-HT Group. The difference was statistically significant (p < 0.05).The rate of extra-thyroid invasiveness and BRAFV600E mutation in HT group were lower than those in PTC group (p < 0.05) .When BRAFV600E mutation was positive, the extrathyroid invasion rate in HT group was still lower than that in PTC group (p < 0.05) .Conclusions: When HT was combined with PTC, the aggressiveness of the lesion was reduced to some extent. When BRAFV600E mutation occurred in PTC, the presence of HT might also hinder the development or invasiveness of PTC. |
| Key words: papillary thyroid carcinoma Hashimoto''s thyroiditis multimodal ultrasound imaging BRAFV600E |
