Objective :To investigate the characteristics of multiodality ultrasound imaging (gray-scale ultrasound, elastography and contrast enhanced ultrasound),invasiveness and BRAFV600E mutation in papillary thyroid carcinoma with Hashimoto''s thyroiditis. Methods: 158 patients with positive PTC were divided into HT group and non-HT Group.The differences of gray-scale ultrasound(border, aspect ratio, microcarcinoma, microcalcification, number of lesions, cervical lymph node metastasis),elastography,contrast-enhanced ultrasound, invasiveness and BRAFV600E mutation between the two groups were compared. Results: There was no significant difference between the two groups in gray-scale ultrasound, elastography and contrast-enhanced ultrasound. There were more female patients in HT group than those in non-HT Group. The difference was statistically significant (p < 0.05).The rate of extra-thyroid invasiveness and BRAFV600E mutation in HT group were lower than those in PTC group (p < 0.05) .When BRAFV600E mutation was positive, the extrathyroid invasion rate in HT group was still lower than that in PTC group (p < 0.05) .Conclusions: When HT was combined with PTC, the aggressiveness of the lesion was reduced to some extent. When BRAFV600E mutation occurred in PTC, the presence of HT might also hinder the development or invasiveness of PTC.