Objective To systematically review the value of contrast-enhanced ultrasound (CEUS) in the detection of active Crohn’s disease (CD). Methods Literatures that evaluated the diagnostic potency of CEUS in CD until January 2020 were searched in databases including PubMed, Embase, The Cochrane Library, CNKI, Wan Fang and VIP. Two researchers screened the literature, extracted the data, and evaluate the risk of bias of included studies based on the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. The meta-analysis was performed using Meta Disc 1.4 and Stata 12.0 software. Results A total of 16 articles were included, involving 18 studies. The results of meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio(DOR) were 0.94[95%CI(0.92,0.96)]、0.76[95%CI(0.71,0.81)]、3.3[95%CI(2.6,4.1)]、0.07[95%CI(0.03,0.18)]、64.72[95%CI(27.87,150.28)] respectively. The areas under the curves (AUROC) was 0.92. Subgroup analysis showed that the enhanced curve had the highest diagnostic value (area under the curve 95%), while the presence enhancement, enhancement patterns, and relative enhancement were less useful (area under the curve 92%, 93%, 85% respectively). Conclusion CEUS has high accuracy in the detection of active CD, especially under the condition of using the enhanced curve parameter as the threshold.