| 摘要: |
| 目的 系统评价超声造影对克罗恩病活动性的诊断价值。 方法 计算机检索PubMed、EMbase、The Cochrane Library等外文数据库和中国知网、万方、维普等中文数据库中有关超声造影诊断克罗恩病活动性的诊断性试验,检索时间为建库至2020年1月,由两名研究员筛选文献,提取数据,使用QUADAS-2工具评价纳入研究的偏倚风险,采用Meta Disc 1.4和Stata 12.0软件进行Meta分析。结果 共纳入16篇文献的18个研究,Meta分析结果显示：超声造影诊断克罗恩病活动性的合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值比分别为0.94[95%CI(0.92,0.96)]、0.76[95%CI(0.71,0.81)]、3.3[95%CI(2.6,4.1)]、0.07[95%CI(0.03,0.18)]、64.72[95%CI(27.87,150.28)],曲线下面积为0.92。亚组分析显示：增强曲线的诊断价值最高(曲线下面积为95%),而存在增强、增强模式、相对增强的诊断价值相对较低(曲线下面积分别为92%、93%、85%)。结论 超声造影对诊断克罗恩病活动性具有明确的诊断价值,特别是在使用增强曲线参数作为阈值的条件下。 |
| 关键词: 克罗恩病 超声造影 系统评价 Meta分析 |
| DOI： |
| 投稿时间：2020-02-07修订日期：2020-02-26 |
| 基金项目: |
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| Diagnostic value of contrast-enhanced ultrasonography for Crohn’s disease activity: a systematic review |
| TANG Xue-yao,XUAN Ji-qing,LI Xuan,LI Ming-xing |
| (Department of Ultrasound,The Affiliated Hospital of Southwest Medical University) |
| Abstract: |
| Objective To systematically review the value of contrast-enhanced ultrasound (CEUS) in the detection of active Crohn’s disease (CD). Methods Literatures that evaluated the diagnostic potency of CEUS in CD until January 2020 were searched in databases including PubMed, Embase, The Cochrane Library, CNKI, Wan Fang and VIP. Two researchers screened the literature, extracted the data, and evaluate the risk of bias of included studies based on the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool. The meta-analysis was performed using Meta Disc 1.4 and Stata 12.0 software. Results A total of 16 articles were included, involving 18 studies. The results of meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio(DOR) were 0.94[95%CI(0.92,0.96)]、0.76[95%CI(0.71,0.81)]、3.3[95%CI(2.6,4.1)]、0.07[95%CI(0.03,0.18)]、64.72[95%CI(27.87,150.28)] respectively. The areas under the curves (AUROC) was 0.92. Subgroup analysis showed that the enhanced curve had the highest diagnostic value (area under the curve 95%), while the presence enhancement, enhancement patterns, and relative enhancement were less useful (area under the curve 92%, 93%, 85% respectively). Conclusion CEUS has high accuracy in the detection of active CD, especially under the condition of using the enhanced curve parameter as the threshold. |
| Key words: Crohn’s disease Contrast-enhanced ultrasonography Systematic review Meta-analysis |
