[Summary] Purpose To observe the changes of right ventricular function and volume in patients with chronic renal failure before and after continuous renal replacement therapy (CRRT) using color Doppler ultrasound. Method Seventy-one patients with chronic renal failure who underwent continuous renal replacement therapy were selected. Echocardiographic examination of patients in the critical care department before and after continuous renal replacement therapy to collect the parameters of the right ventricle, including tricuspid annular plane systolic excursion (TAPSE), right ventricular fractional area change (FAC), tricuspid annular systolic peak speed (S’),right ventricular end diastolic volume (RVEDV), inner diameter of right ventricular basal segment [RVDd (base)].The changes of right ventricular function and volume parameters in patients with chronic renal failure before and after continuous renal replacement therapy were compared,and explore the correlation between TAPSE and CVP before continuous renal replacement therapy in patients with chronic renal failure. Result Compared with before continuous renal replacement therapy, RV EDV and [RVDd (base)] after continuous renal replacement therapy were lower than before treatment,the difference was statistically significant (P＜0.05).There was no significant difference between S 'before and after continuous renal replacement therapy.The TAPSE before continuous renal replacement therapy was (15.37±4.45) mm, the TAPSE after continuous renal replacement therapy increased by (16.89±5.01) mm,the difference was statistically significant (P＜0.05). The FAC before continuous renal replacement therapy was (46.12±10.57) mm, and the FAC after CRRT increased by (48.88±11.90) mm,the difference was statistically significant (P <0.05).Correlation between TAPSE and CVP before continuous renal replacement therapy in patients with chronic renal failure (r=-0.592, P=0.000). Conclusion TAPSE and FAC can roughly reflect right ventricular systolic function. After continuous renal replacement therapy, TAPSE and FAC increase in patients with chronic renal failure than before treatment, suggesting that continuous renal replacement therapy can improve chronic renal failure. The right ventricular systolic function of the patient RVEDV, [RVDd (base)] reflects right ventricular volume, suggesting that continuous renal replacement therapy can reduce right ventricular volume. CVP increases with the decrease of TAPSE, suggesting that TAPSE may become an indirect indicator of response capacity.