| 摘要: |
| 【摘要】目的：探讨超声造影（CEUS）定量参数与甲状腺乳头状癌（PTC）甲状腺外侵犯（ETE）的相关性。材料和方法:回顾性分析2013年 2 月至 2019年 11月在江苏大学附属人民医院就诊的甲状腺乳头状癌（PTC）患者 112例（157枚结节），术前均行 CEUS 检查，对 PTC 有ETE组和无ETE 组的大小、内部回声、边缘、血流信号、纵横径比、增强方式、均匀性和增强强度等变量进行 χ2 检验或 Mann-Whitney U 检验，再采用 Logistic 回归分析筛选PTC的ETE的危险因素，进一步绘制定量分析参数峰值半降时间(time from peak to one half，TPH)、上升支斜率(wash in slope，WIS)和肿瘤最大径诊断PTC的ETE的ROC曲线，以约登指数最大为最佳截断值，判断各定量参数诊断PTC的ETE的敏感性、特异性。结果：CEUS的定性特征（肿瘤最大径）在PTC 有ETE和无ETE 组之间差异有统计学意义(P< 0.05)。多元Logistic回归分析显示肿瘤最大径、TPH和WIS是诊断PTC的ETE的独立危险因素（OR＝3.688、0.892、9.758，P＜0.05），定量分析参数以TPH诊断PTC的ETE价值最大，其ROC曲线下面积0.805，最佳截断值为60.96， 诊断PTC的ETE敏感性、特异性分别88.3％、60.8％。结论：CEUS的TPH和WIS和肿瘤最大径与诊断PTC的ETE具有相关性。 |
| 关键词: 超声检查 甲状腺肿瘤 甲状腺外侵犯 超声造影 定量参数 |
| DOI： |
| 投稿时间：2020-02-19修订日期：2020-03-23 |
| 基金项目:国家自然科学批准号 81771848,项目名称:超声导航下乳腺癌纳米声动力学协同治疗研究 |
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| Correlation between quantitative parameters of contrast-enhanced ultrasound and extramedullary invasion of thyroid papillary carcinomaNi enzhen 1Zhang guoliang 3 Zhang jin 2 Zhang heng1 Xu feiju 2 Qian xiaoqin2 Wang xian2* |
| ni en zhen,zhang guo liang,zhang jin,zhang heng,xu fei ju,qian xiao qin,wang xian |
| () |
| Abstract: |
| 【Abstract】 Objective：To investigate the correlation between CEUS quantitative parameters and extrathyroidal extension (ETE) of thyroid papillary carcinoma (PTC). Materials and methods: A retrospective analysis in February 2013 to November 2019 in the affiliated Renmin Hospital,Jiangsu University,of papillary thyroid carcinoma (PTC), 112 cases of patients (157 nodules), preoperative CEUS in check, for PTC with ETE and without ETE group, internal echo,the size of the edge, blood flow signal, vertical ,horizontal diameter ratio, strengthen, uniformity, and enhance the strength of variables do chi-square test or the Mann - Whitney U test, then using Logistic regression analysis of risk factors for the screening of PTC ETE, further drawn half quantitative analysis parameters of the peak down time (time from peak to one half, TPH), increase the slope (wash in slope, WIS) and tumor size in the diagnosis of ROC curve, the maximum yoden index is the best boundary point, determine the quantitative parameters sensitivity, specificity of diagnosis of PTC ETE. Results: The qualitative characteristics (tumor size) of CEUS were significantly different between the PTC with ETE and without ETE group (P< 0.05). The difference of CEUS 'peak intensity (PI) between PTCwith ETE and without ETE group was statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that tumor size, TPH, and WIS were independent risk factors for the ETE that diagnosed PTC (OR =3.688、0.892、9.758, P < 0.05). For the quantitative analysis parameters, the ETE value that diagnosed PTC with TPH value was the largest, and its area under the ROC curve was 0.805.The best cut-off value is 60.96 ,sensitivity and specificity were 88.3％、60.8％. Conclusion: The TPH and WIS of CEUS and tumor size were correlated with the ETE of PTC diagnosis. |
| Key words: ultrasonic examination thyroid tumor extrathyroidal extension ultrasound contrast The quantitative parameters |
