| 摘要: |
| 目的：探讨甲状腺癌超声血管化指数(VI)与临床病理特征、肿瘤标志物及血管新生指标的关系。方法：回顾性选取2017年10月至2019年10月我院收治的甲状腺癌患者60例作为甲状腺癌组,甲状腺腺瘤患者60例作为甲状腺腺瘤组,收集其临床资料,比较两组血管化指数(VI)、血清肿瘤标志物及血管新生指标水平,单因素分析甲状腺癌患者临床病理特征与VI值的关系,Pearson相关性分析甲状腺癌患者VI与血清肿瘤标志物及血管新生指标的相关性。结果：甲状腺癌组VI值、血清甲状腺球蛋白(TG)、癌胚抗原(CEA)、半乳糖血凝素-3(Gal-3)、血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)、胰岛素样生长因子-II(IGF-II)水平显著高于甲状腺腺瘤组(P<0.05)。甲状腺癌患者VI水平与性别、肿瘤直径、病理分型无关(P>0.05),与TNM分期、淋巴结转移有关(P<0.05)。经Pearson相关分析显示,甲状腺癌患者VI水平与血清TG、CEA、Gal-3、VEGF、Ang-2、IGF-II水平呈正相关(P<0.05)。结论：甲状腺癌患者VI值明显升高,其水平与TNM分期、淋巴结转移有关,且与血清肿瘤标志物及血管新生指标水平均呈正相关,可作为临床诊断及评估甲状腺癌患者病情的重要参考指标。 |
| 关键词: 甲状腺癌 血管化指数 肿瘤标志物 血管生成 相关性 诊断 |
| DOI： |
| 投稿时间：2020-02-20修订日期：2020-02-20 |
| 基金项目:东莞市社会科技发展(一般)项目,项目编号：201950715001366 |
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| The relationship between ultrasound vascularization index and clinicopathological features, tumor markers and angiogenesis in thyroid cancer |
| Liang Li-mei,Liu Shao-ming,Yuan Jian-jun,Chen Jun-jun,Yuan Zhi-fan,He Wen-xu,He Zhi-zhong |
| (Department of Ultrasonography,Dongguan People''''s Hospital Affiliated to Southern Medical University,Dongguan,Guangdong,523000) |
| Abstract: |
| Objective: To investigate the relationship between the ultrasonic vascular index (VI) and the clinicopathological features, tumor markers and angiogenesis indexes of thyroid cancer. Methods: 60 patients with thyroid cancer in our hospital from October 2017 to October 2019 were selected as thyroid cancer group, 60 patients with thyroid adenoma as thyroid adenoma group. The levels of Vascularization index (VI), tumor markers and angiogenesis were compared between the two groups. The relationship between clinicopathological characteristics and VI value of thyroid cancer patients was analyzed by single factor analysis, and the correlation between VI and serum tumor markers and angiogenesis indicators was analyzed by Pearson correlation analysis. Results: The VI value, Serum thyroglobulin (TG), Carcinoembryonic antigen (CEA), Galactohydrin-3 (Gal-3), Vascular endothelial growth factor (VEGF), Angiopoietin-2 (Ang-2), Insulin like growth factor II (IGF-II) of thyroid cancer group were higher than those of thyroid adenoma group (P < 0.05). The level of VI was not related to gender, tumor diameter and pathological type (P > 0.05), but to TNM stage and lymph node metastasis (P < 0.05). The Pearson correlation analysis showed that the level of VI was positively correlated with the level of TG, CEA, Gal-3, VEGF, Ang-2 and IGF-II (P < 0.05). Conclusion: The value of VI in patients with thyroid cancer is significantly increased, which is related to TNM stage, lymph node metastasis, and is positively related to the level of serum tumor markers and angiogenesis indicators. It can be used as an important reference index for clinical diagnosis and evaluation of patients with thyroid cancer. |
| Key words: Thyroid cancer Vascularization index Tumor markers Angiogenesis Correlation Diagnosis |
