Objective To investigate the application of acoustic radiaction force impulse imaging technique(ARFI) in evaluating the differential diagnosis of hysteromyoma degeneration. Methods 115 cases of hysteromyoma confirmed by surgical pathology were divided into two groups: degenerated and undegenerated groups. All were detected by ARFI, and conventional ultrasound images, stress-elastic images, acoustic palpation tissue imaging（VTI）and shear wave velocity (VTQ),which were all recorded and analysed with statistics. Results There was no significant difference in the internal echo of uterine fibroids between the degeneration group and the undenatured group, and the larger diameters were more likely to be degenerated. The stress-type elastic score, area ratio and VTQ of the degeneration group were lower than those of the undenatured group, and the difference was statistically significant (P<0.05).The VTQ level of the degenerated group was lower than the undegenerated group, meanwhile the difference was statistically significant (P<0.05). The area under the ROC curve was 0.72, and the cutoff value was 2.52 m/s. At this present, the sensitivity, specificity and accuracy of hysteromyoma degeneration were 65.52%, 79.10% and 88.69 % respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ARFI technique combined with stress-type elastography for the assessment of uterine fibroid degeneration were 86.36%, 96.59%, 70.37%, 91.40% and 90.43%, respectively. ARFI technology or in combination with stress elastography can significantly improve diagnostic accuracy. Conclutions ARFI technology can provide quantitative indicators of tissue hardness, and combined with stress-based elastography can significantly improve the diagnostic accuracy and contribute to the differential diagnosis of uterine fibroids.