Objective: To explore the value of automated breast ultrasound system (ABUS) in the diagnosis of breast minimum nodules. Methods: a retrospective analysis of 75 patients with breast minimum nodules admitted to our hospital from August 2016 to November 2019 was carried out. All patients were examined by ABUS and 2D breast ultrasound to detect the location of the lesions, then diagnosis benign and malignant lesions.The results were compared with the postoperative pathological results (the gold standard). Results: There were 75 patients with 96 minimum nodules which were confirmed by surgeries. The maximum diameters of 65 nodules were 0.5-1.0cm, 31 ones were less than 0.5cm. 89 lesions were found by 2D ultrasound, 96 lesions were found by ABUS. The detection rate of 2D ultrasound (92.71%) was lower than ABUS (100%). Compared to pathology results of lesions, sensitivity, specificity and accuracy rate of 2D ultrasound were 80.77% (21/26),95.24%(60/63) and 91.01%(81/89). The sensitivity, specificity and accuracy rates of ABVS were 89.29%(25/28),98.53%(67/68) and 95.83%(92/96). There were significant differences between these two methods(p＜0.05). For localization diagnosis, the missed diagnosis parts of minimum nodules by 2D ultrasound were mammary areola part and 4.5cm far from nipple when compared to ABUS. Conclusion: ABUS can avoid operator dependence, and diagnosis minimum nodules accurately, which can provide the basis for early diagnosis of small breast cancer.