AbstractObjective To evaluate the left ventricular systolic function of patients with hyperuricemia (HU) and its correlation with serum uric acid (SUA) by three-dimensional speckle tracking technology (3D-STI), and to explore possible predictors of early myocardial damage. Methods 25 hyperuricemia patients (HU group) and 30 healthy volunteers (control group) matched by sex and age were collected. All subjects were measured by conventional two-dimensional echocardiography and the measured parameters were compared. At the same time, 3D-STI was applied to measure the global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and global area strain (GAS) of the left ventricle. 3D-STI parameters were compared between groups, and correlation analysis was made with SUA value to determine whether there was correlation between the two. The ROC curve analysis was used to compare the clinical value of 3D-STI parameters in diagnosing left ventricular systolic dysfunction in HU patients. Results Compared with the control group, LAD、LVEDD、LVESD、LVEDV、LVESV及LVEF had no significant difference; the left ventricular GLS, GCS and GAS in HU group were significantly reduced, and the difference was statistically significant (P <0.05). Correlation analysis showed that SUA was negatively correlated with GLS and GCS,the correlation coefficients were -0.571 and -0.463.ROC curve shows that GLS has a large area under the curve. When GLS 20.35% is taken as the cutoff point, the sensitivity is 95%, specificity is 66%, and Youden index is 0.61. Conclusion Left ventricular systolic function of HU patients is significantly reduced. 3D-STI can evaluate the changes of left ventricular systolic function in early stage.