| 摘要: |
| 摘要 目的 应用三维斑点追踪技术（3D-STI）评价高尿酸血症（HU）患者的左心室心肌收缩功能，及其与血尿酸（SUA）的相关性分析，并探索早期心肌受损可能的预测指标。方法25例选取高尿酸血症患者（HU 组）和30例性别、年龄匹配的健康志愿者（对照组）。 所有研究对象均行常规二维超声心动图测量并比较测量参数，同时应用3D-STI测量左室整体纵向应变（GLS）、整体径向应变（GRS）、整体圆周应变（GCS）、整体面积应变（GAS），并与SUA值进行相关性分析；通过ROC曲线分析比较3D-STI参数诊断HU患者左室收缩功能损害的临床价值。 结果 与对照组相比，LAD、LVEDD、LVESD、LVEDV、LVESV及LVEF差异无统计学意义（p>0.05）；HU组左室GLS、GCS、GAS均明显减低，差异有统计学意义（p<0.05）。相关性分析结果显示SUA与GLS、GCS呈线性负相关，相关系数分别为-0.571、-0.463，（p<0.05）。 ROC曲线显示，GLS 的曲线下面积较大，以 GLS 20.35%为截断点时，灵敏度为95%，特异度为66%，Youden指数为0.61。结论 HU患者左室心肌收缩功能明显减低。3D-STI 能够早期评估左室整体收缩功能的改变。 |
| 关键词: 三维斑点追踪成像 高尿酸血症 左室收缩功能 |
| DOI： |
| 投稿时间：2020-03-24修订日期：2020-03-28 |
| 基金项目: |
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| Evaluation of Left Ventricular Systolic Function in Hyperuricemia Patients by Three-dimensional Speckle Tracking Technique |
| Zhao Yang,Jiang Yanna |
| () |
| Abstract: |
| AbstractObjective To evaluate the left ventricular systolic function of patients with hyperuricemia (HU) and its correlation with serum uric acid (SUA) by three-dimensional speckle tracking technology (3D-STI), and to explore possible predictors of early myocardial damage. Methods 25 hyperuricemia patients (HU group) and 30 healthy volunteers (control group) matched by sex and age were collected. All subjects were measured by conventional two-dimensional echocardiography and the measured parameters were compared. At the same time, 3D-STI was applied to measure the global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and global area strain (GAS) of the left ventricle. 3D-STI parameters were compared between groups, and correlation analysis was made with SUA value to determine whether there was correlation between the two. The ROC curve analysis was used to compare the clinical value of 3D-STI parameters in diagnosing left ventricular systolic dysfunction in HU patients. Results Compared with the control group, LAD、LVEDD、LVESD、LVEDV、LVESV及LVEF had no significant difference; the left ventricular GLS, GCS and GAS in HU group were significantly reduced, and the difference was statistically significant (P <0.05). Correlation analysis showed that SUA was negatively correlated with GLS and GCS,the correlation coefficients were -0.571 and -0.463.ROC curve shows that GLS has a large area under the curve. When GLS 20.35% is taken as the cutoff point, the sensitivity is 95%, specificity is 66%, and Youden index is 0.61. Conclusion Left ventricular systolic function of HU patients is significantly reduced. 3D-STI can evaluate the changes of left ventricular systolic function in early stage. |
| Key words: 3D speckle tracking imaging hyperuricemia left ventricularsystolic function |
