Objective : To investigate the differential diagnostic value of Artificial Intelligence Computer Aided system with Contrast-Enhanced Ultrasonography for thyroid TI‐RADS 5 nodules．Methods：93cases with thyroid nodules diagnosed by AI-CAD and CEUS had been treated in our hospital,All cases are confirmed by pathology,compare the sensitivity,specificity,positive predictive value,negative predictive value and diagnostic coincidence rate of AI-CAD diagnosis,CEUS diagnosis and combined application.Results:Ninety-three patients with 141 thyroid nodules(including 87 benign nodules and 54 malignant nodules),The sensitivity and specificity of AI-CAD diagnosis were 78.2% and 85.2%,and for CEUS diagnosis were 89.7% and 63.0%,while for combined application were 94.3% and 63%.Conclusion: AI-CAD and CEUS is very helpful in differential diagnosis of thyroid TI‐RADS 5 nodules.Combined using both methods can significantly increase the diagnostic coincidence rate of thyroid TI‐RADS 5 nodules.