【Abstract】 Objective To explore the value of quantitative analysis of contrast ultrasound in the differential diagnosis of delayed-phase clearance of liver inflammatory lesions. Method A total of 38 patients with hepatic inflammatory lesions confirmed by surgery or biopsy were subjected to conventional ultrasound, contrast-enhanced ultrasound (CEUS) and quantitative analysis of contrast ultrasound, and compared with HCC lesions performed at the same time. Result There were differences in clinical characteristics such as gender, symptoms, history of CA125, AFP, and hepatitis B virus infection between the hepatitis lesion group and the HCC group (P <0.05). CEUS feature analysis showed that compared with HCC, the enhanced morphology of the hepatitis lesions was irregular and the borders were unclear (P <0.01); compared with HCC, the enhancement intensity of portal phase was low for the hepatitis lesions; : 8: 0 vs26: 34: 6, there is a significant difference in the degree of portal phase enhancement, the difference is statistically significant (P <0.01). CEUS quantitative analysis showed that the area under the enhancement curve (AUC) of hepatitis lesions was significantly greater than that of HCC (P <0.01); the decline time and average transit time of hepatitis lesions were shorter than HCC (P <0.05). In the CEUS quantitative analysis, the sensitivity and specificity of the statistically significant univariate distinction between hepatitis lesions and HCC were 92.4-100.0% and 68.2-73.7%, respectively. After the variables were included in the logistic regression analysis, in the quantitative analysis of identifying hepatic lesions and HCC, enhancing AUC> 365.281 may help to correctly diagnose hepatic lesions. Conclusion CEUS provides important information for the differential diagnosis of hepatic lesions and HCC with delayed phase clearance. Quantitative analysis of CEUS can more objectively show the characteristics of blood perfusion of hepatic inflammatory lesions, and has good clinical application value.