| 摘要: |
| 应用三维斑点追踪（3D-STI）技术评价2型糖尿病（T2DM）合并高尿酸血症（HU）患者左室整体收缩功能，分析T2DM患者左室各方向整体应变的影响因素。方法选取62例T2DM患者并根据是否合并HU分为单纯T2DM组33例和T2DM+HU组29例，另选健康体检者40例（对照组），各组均行常规和三维超声心动图检测，存储图像并应用3D-STI分析软件在线分析，采用单因素方差分析比较各组间3D-STI参数的差异，广义线性模型分析其可能的影响因素。结果 T2DM组左室整体纵向应变（GLS）低于对照组，差异有统计学意义（P＜0.05），左室整体圆周应变（GCS）、面积应变（GAS）及径向应变（GRS）与对照组比较差异均无统计学意义。T2DM+HU组GLS、GAS、GCS及GRS均低于对照组和T2DM组，差异均有统计学意义（均P＜0.05）。空腹血糖和血尿酸是左室各方向整体应变值的独立影响因素。结论在左室射血分数正常情况下，T2DM患者左室整体收缩功能已经受损，合并HU者进一步加重；3D-STI可以早期敏感地检测出左室收缩功能的改变，为临床提供可靠依据 |
| 关键词: 三维斑点追踪 2型糖尿病 高尿酸血症 左心室收缩功能 |
| DOI： |
| 投稿时间：2020-04-08修订日期：2020-11-14 |
| 基金项目: |
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| Evaluation of left ventricular global systolic function in patients with type 2 diabetes mellitus complicated with hyperuricemia by three- dimensional speckle tracking imaging |
| Zhao Yang,Jiang Yanna,Xu Sheng |
| (Department of Ultrasound,Liaoning Jinqiu Hospital) |
| Abstract: |
| ABSTRACT objective To analyze the left ventricular global systolic function with 3D speckle tracking imaging （3D-STI） in patients with type 2 diabetes mellitus complicated with hyperuricemia，analyze the influencing factors of left ventricular strain in all directions in T2DM patients.MethodsSixty-two patients with T2DM（case group） were collected and divided into T2DM group（33 cases） and T2DM+HU group（29 cases），and healthy control group（40 cases）.All subjects were tested by conventional and three-dimensional echocardiography，stored images and analyzed online with 3D-STI analysis software，single factor analysis of variance was used to compare the differences of parameters，analysis of possible influencing factors with generalized linear model.Results compared with control group，GLS in T2DM group was lower（P＜0.05）.There was no significant difference in GAS，GCS and GRS between the two groupscompared with control group，GLS，GAS，GCS and GRS in T2DM+HU group were lower（P＜0.05）.compared with T2DM group，GLS，GAS，GCS and GRS in T2DM+HUgroup were lower（P＜0.05）.FPG and uric acid are independent influencing factors of left ventricular strain in all directions.ConclusionUnder the condition of normal ejection fraction，the overall systolic function of the left ventricle in patients with type 2 diabetes mellitus has been damaged，which is further aggravated by hyperuricemia.3D-STI can sensitively detect the changes of the systolic function of the left ventricle at an early stage，provide basis for clinic. |
| Key words: 3D speckle tracking imaging type 2 diabetes mellitus hyperuricemia left ventricular systolic function |
