Bedside ultrasound can timely estimate the progress of coronavirus disease 2019 (COVID-19) patients’ condition, and provide a basis for clinical diagnosis and treatment. But ultrasound doctors need to be in close contact with patients, the risk of virus exposure is high. How to safely carry out bedside ultrasound diagnosis and treatment in the isolation ward has become the focus of attention. This paper made a statistical analysis of the diagnosis and treatment of bedside ultrasound in COVID-19 isolation ward in Guanggu district of our hospital, summarized the operation process and protection experience, in order to provide reference for the formulation of standardized bedside ultrasound implementation strategy in isolation ward.