Abstract: Objective To investigate the clinical value of pulmonary ultrasound score in predicting neonatal respiratory distress syndrome (NRDS) combined with bronchopulmonary dysplasia (BPD).Methods Lung ultrasonography was performed on 158 children with NRDS, and lung ultrasound scores were calculated according to standards, and general clinical data of the children were collected.Cases were divided into BPD and non-BPD groups based on whether they had bronchopulmonary dysplasia (BPD), the differences in pulmonary ultrasound scores and clinical data between the two groups were compared.The pulmonary ultrasound score was analyzed to predict the clinical value of NRDS combined with BPD, and the correlation between the pulmonary ultrasound score and different treatment methods was explored.Results Lung ultrasound scores in the BPD group were higher than those in the non-BPD group (P <0.001).There were significant differences in gestational age and birth weight between the two groups of children (P <0.05).There were also differences in the length of hospital stay, continuous positive airway pressure, mechanical ventilation time, and Apgar score (P<0.05).There were no significant differences in gender, number of twins, number of children receiving conventional oxygen therapy, and incidence of intrauterine infection and neonatal pneumonia between the two groups (P> 0.05).Pulmonary ultrasound score predicts the area under the ROC curve of BPD is 0.832, the best score cutoff is 37 points, sensitivity is 78%, specificity is 89%, positive predictive value, negative predictive value.There was a positive correlation between pulmonary ultrasound scores and respiratory therapy (r = 0.47, P <0.05).Conclusion Pulmonary ultrasound scoring method is helpful for predicting whether children with NRDS are associated with BPD and provides a basis for respiratory treatment in severe children.