Transcranial direct current stimulation, transcranial magnetic stimulation, and deep brain stimulation have been widely used in the treatment of various neurological / psychiatric diseases (such as Parkinson"s, epilepsy, depression), but there are still shallow DC stimulation Transcranial magnetic stimulation has limited accuracy and other limitations. In recent years, with the research progress on the biological effects of ultrasound, low intensity ultrasound (LIUS) transcranial brain stimulation is a new neuromodulation method for treating neurological diseases, because of its non-invasive and high spatial resolution. And the advantages of high cost performance, and it is favored by researchers. LIUS mainly works through non-thermal effects, and has made great progress in the treatment of many neurological diseases (such as traumatic brain injury, ischemic stroke, Alzheimer"s disease, etc.). This article reviews the main research progress and related issues in the treatment of cerebral neurological diseases in recent years.