AbstractObjective The aim of this study was to investigate the different shear wave elastography (SWE) in different wrist positions ofthemedian nerve from healthy individuals.Methods The study included 56 healthy volunteers (112 wrists). The difference of shear wave velocity was compared between the proximal and distal carpal bones and the correlation was analyzed with age, sex, and BMI. Results The shear wave velocity at the proximal carpal bone level of the middle nerve was 3.80±0.45 m/s,95% the confidence interval was (3.67,3.93) m/s; The shear wave velocity at the distal carpal bone level was 4.63±0.47,95% the confidence interval was (4.49,4.76) m/s. The shear wave velocity of the median nerve was positively correlated with age. The shear wave velocity in the same position of the median nerve was statistically significant different in different sex. Conclusion The shear wave velocity ofthemedian nerve in different regions of the wrist is different. Sex and age are both important factors affecting the shear wave velocity, and these can provide reference for further clinical studies.