Objective A comparative research on diagnostic effects of the Exercise electrocardiography（EXECG） and contrast-enhanced ultrasound test for Coronary Artery Disease（CAD） will be carried out. Methods This paper takes 120 patients with coronary heart disease who are presently in stable condition and not taken any coronary stent implantation or coronary artery bypass graft as the research object.These patients are treated in our hospital between January 2018 and December 2019.Coronary angiography（CAG） verifies that at least one of the main branches（including anterior descending branch，circumflex branch，right coronary artery） of the coronary artery has fairly narrow microbores to the extent of more than 50%.Check this by EXECG and treadmill exercise stress contrast-enhanced ultrasound，and use CAG as the gold standard，to evaluate the sensitivity，specificity and accuracy of CAD diagnose by these two different ways. Results The sensitivity，specificity and accuracy of CAD diagnose by EXECG were 58%，83% and 72%，when microbores of at least one of the main branches of the coronary artery were narrower by 50%；when microbores were narrower by 75%，the sensitivity，specificity and accuracy would increase to 63%，89% and 79% respectively The degree of narrowness ≥50% has a significant increase, In the meantime，the statistical difference was revealed with P＜0.05；the sensitivity，specificity and accuracy were 77%，92% and 85% when the narrowness was more than 50%，which were higher than those of the EXECG treadmill with statistical difference of P＜0.05；when the narrowness was more than 75%，the sensitivity，specificity and accuracy increased to 85%，96% and 91%，which were also higher than those of the EXECG treadmill with statistical difference of P＜0.05.Conclusion The sensitivity，specificity and accuracy of the EXECG treadmill exercise in diagnosing ischemia of the coronary heart disease are lower than those of the treadmill exercise stress contrast-enhanced ultrasonography. The Treadmill exercise stress contrast-enhanced ultrasonography has a better diagnostic effect on the coronary heart disease.The higher the degree of the coronary stenosis is，the higher diagnostic sensitivity and accuracy of the Treadmill exercise stress contrast-enhanced ultrasonography will be.