[Abstract]: Objective: to evaluate the clinical value of the new fourteen-zone lung ultrasound scoring method in the evaluation of neonatal respiratory distress syndrome (NRDS). Method: From June 2018 to June 2019, 62 NRDS children who were mechanically ventilated in the NICU of our hospital were selected. Bedside lung ultrasound score (LUS) was performed before the patient was ready for extubation after reaching the clinical evacuation standard. LUS was administered by the withdrawal loser before re-intubation and before re-extubation. According to the results, the patients were divided into the success group and the failure group, the LUS of the two groups were compared. The ROC curve was used to analyze the diagnostic efficacy of LUS for the timing of evacuation. Results: Among the 62 children with mechanical ventilation, 49 patients were successfully removed from the machine and 13 patients were not, indicating a statistically significant difference in LUS between the two groups (P＜ 0.05). In the failure group, the following lesions were found by lung ultrasonography: 4 cases of obvious lung edema, 5 cases of extensive lung consolidation, 2 cases of extensive lung consolidation at the bottom of the lung, 1 case of large atelectasis of the upper right lung, and 1 case of no abnormality in lung ultrasonography (cardiac dysfunction was found in the children). Compared with the other three methods, the fourteen-zone lung ultrasound scoring method had a better diagnostic performance for the withdrawal time, and 40.5 point was used as the diagnostic threshold to predict the risk of withdrawal failure. The area under the curve was 0.965, the sensitivity was 92.31%, and the specificity was 93.88%.