Objective：To evaluate the effects of early stage electro-acupuncture treatment to ICUAW in sepsis patients with mechanism ventilation(MV) via bedside diaphragmatic ultrasound. Methods：Seventy-five sepsis patients with mechanism ventilation were enrolled in this study and divided into 3 groups: early-stage intervention group(n=25, Group A), late-stage intervention group(n=25, Group B) and control group(n=25, Group C). Electro-acupuncture treatment was performed within 24h and 72h in group A and B, respectively. All the patients were under MRC score evaluation before weaning. The activity of the right diaphragm, bilateral diaphragmatic thickening fraction(DTF) and bilateral diaphragmatic excursion-time(E-T) index were measured via bedside diaphragmatic ultrasound on day 0, 3, and 7 of enrollment. Results：MV time(t_A=4.387,P<0.001；t_B=3.350,P<0.001) and ICU days(t_A=2.796,P=0.004；t_B=3.027,P=0.002) in group A and B were lower than those in group C. The levels of MRC in group A were higher than those in group C(t=3.433,P<0.001) and group B(t=1.804,P=0.040). The levels of right diaphragm activity, right DFT, left DFT, right E-T and left E-T were higher than those in group C on T2(P<0.05). The relation index between electroacupuncture treatment or early-stage electroacupuncture treatment and diaphragm ultrasound indexes were range from 0.249 to 0.598 and 0.288 to 0.623, respectively. Conclusion：Based on the results of beside diaphragm ultrasound, electro-acupuncture will improve diaphragm dysfunction and reduce MV time and ICU days in sepsis patients with MV.