Calcium pyrophosphate deposition disease is the deposition of calcium pyrophosphate crystals on the hyaline cartilage and fibrous cartilage of the joint, and the tissues around the joint, such as the synovium, tendon, and bursa. It is characterized by calcification of the cartilage and is called pseudogout during an acute attack. The clinical manifestations of calcium pyrophosphate deposition disease are diverse, and the incidence increases with age, so it is of great significance to accurately diagnose it. Ryan-McCarty diagnostic criteria are currently the most widely used, including the presence of calcium pyrophosphate crystals in synovial fluid analysis and typical cartilage calcification under imaging. The application of musculoskeletal ultrasound has increased the sensitivity and specificity of diagnosis. This article reviews the application value of ultrasound in calcium pyrophosphate deposition disease.