| 摘要: |
| 目的 探讨孕早期颈项透明层厚度(NT)、静脉导管(DV)频谱及三尖瓣反流(TR)在复杂心脏畸形(CHD)筛查中的临床价值。方法 回顾性分析2016年1月至2019年8月期间于本院建档并做产前检查孕妇9100例,所有孕妇均于孕11~13+6周进行超声检查,记录NT厚度、DV频谱和TR情况,并对所有孕妇进行随访,将本次检查结果与随访结果相对照。结果 孕11~13+6周共检出NT增厚342例,DV频谱异常181例,TR 163例,NT增厚+DV频谱异常/TR 168例,DV频谱异常+TR 124例,三项指标均为阳性92例。复杂CHD发生率随着NT的增厚呈指数增长(P<0.01),DV频谱异常组、TR组复杂CHD发生率分别高于DV频谱正常组和无TR组(P<0.01),差异均有统计学意义(P<0.01)。NT增厚联合DV频谱异常/TR检测、三项指标联合筛查复杂CHD的敏感性、阳性预测值较高,组间差异无统计学意义(P>0.05),均高于DV频谱异常+TR(P<0.05),也高于各项指标单独检测,差异有统计学意义(P<0.05)。结论 NT增厚、DV血流频谱异常及TR是针对复杂CHD诊断的有效指标。 |
| 关键词: 先天性心脏畸形 颈项透明层厚度 静脉导管频谱 三尖瓣反流 |
| DOI： |
| 投稿时间：2020-06-24修订日期：2020-07-27 |
| 基金项目: |
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| The value of nuchal translucency, duct venous frequency spectrum and tricuspid regurgitation in the screening of fetal complex cardiac abnormalities in early pregnancyLi Hui-lan, Cao Rui, Li Jin, Lei Hui, Hu Wei (Department Of Ultrasound imaging, Nanshan Maternal and child health hospital, Shenzhen Guangdong 518000) |
| Li Hui-lan,caorui,lijing |
| () |
| Abstract: |
| Objective To investigate the clinical value of nuchal translucency (NT), ducts venous (DV), and tricuspid regurgitation (TR) in the screening of congenital heart disease (CHD) in early pregnancy. Methods A total of 9100 pregnant women who were registered and had prenatal examinations in our hospital from January 2016 to August 2019 were selected. All pregnant women underwent ultrasound examination at 11~13+6 weeks of gestation, and NT, DV spectrum and TR were recorded, and all pregnant women were followed up. The results of this examination were compared with the results of follow-up. Results A total of 342 cases of NT thickening, 181 cases of DV spectrum anomalies, 163 cases of TR, 168 cases of NT thickening + DV spectrum anomalies/TR, 124 cases of DV spectrum anomalies + TR, and 92 cases of all the three indicators were detected at 11~13+6 weeks of gestation. The incidence of complex CHD increased with the thickening of NT (P<0.01). The incidence of complex CHD in the DV spectrum anomaly group and TR group was respectively higher than that in the DV spectrum normal group and the TR free group (P<0.01), and the differences were statistically significant. The sensitivity,positive predictive value of NT thickening combined with DV spectrum anomaly/TR detection to screen complex CHD were relatively high, and the differences between the groups were not statistically significant (P> 0.05), which were all higher than DV spectral anomaly +TR (P<0.05), and were also higher than the independent detection of each indicator, with statistically significant differences (P<0.05). Conclusion The incidence of complex CHD was high in fetuses with NT thickening, abnormal DV spectrum and TR in early pregnancy, NT thickening combined with DV flow spectrum anomaly and/or TR has high predictive value for complex CHD. |
| Key words: congenital heart disease nuchal translucency ducts venous spectrum tricuspid regurgitation |
