Objective To investigate the clinical value of nuchal translucency (NT), ducts venous (DV), and tricuspid regurgitation (TR) in the screening of congenital heart disease (CHD) in early pregnancy. Methods A total of 9100 pregnant women who were registered and had prenatal examinations in our hospital from January 2016 to August 2019 were selected. All pregnant women underwent ultrasound examination at 11~13⁺⁶ weeks of gestation, and NT, DV spectrum and TR were recorded, and all pregnant women were followed up. The results of this examination were compared with the results of follow-up. Results A total of 342 cases of NT thickening, 181 cases of DV spectrum anomalies, 163 cases of TR, 168 cases of NT thickening + DV spectrum anomalies/TR, 124 cases of DV spectrum anomalies + TR, and 92 cases of all the three indicators were detected at 11~13⁺⁶ weeks of gestation. The incidence of complex CHD increased with the thickening of NT (P<0.01). The incidence of complex CHD in the DV spectrum anomaly group and TR group was respectively higher than that in the DV spectrum normal group and the TR free group (P<0.01), and the differences were statistically significant. The sensitivity,positive predictive value of NT thickening combined with DV spectrum anomaly/TR detection to screen complex CHD were relatively high, and the differences between the groups were not statistically significant (P> 0.05), which were all higher than DV spectral anomaly +TR (P<0.05), and were also higher than the independent detection of each indicator, with statistically significant differences (P<0.05). Conclusion The incidence of complex CHD was high in fetuses with NT thickening, abnormal DV spectrum and TR in early pregnancy, NT thickening combined with DV flow spectrum anomaly and/or TR has high predictive value for complex CHD.