| 摘要: |
| [摘要] 目的 采用Meta分析评价增强超声鉴别诊断脾脏良恶性占位的价值。
资料与方法 从Google scholar、PubMed、Embase、维普、万方、CNKI等数据库检索增强超声鉴别诊断脾脏良恶性占位方面的文献，检索时间从数据库建立到2020年3月10日。由两名研究人员分别对文献进行综合筛选及数据提取。运用QUADAS工具对入选相关文献的质量水平进行综合评价，文献分析采用STATA15.1。结果 研究共19篇（样本量共776例，共875个占位，良性515个，恶性360个）纳入统计分析。统计分析结果显示：增强超声鉴别诊断脾脏良恶性占位的合并敏感度为0.97[95%CI：0.91,0.99]，合并特异度为0.91[95%CI：0.87,0.93]，合并阳性似然比为10.5[95%CI：7.7,14.4]，合并阴性似然比为0.04[95%CI：0.01,0.10]，合并诊断比值比为274 [95%CI：96,781]，合并曲线下面积为0.97[95%CI：0.95,0.98]，敏感度Q检验的P＜0.01，I2统计量为65.63%，说明各项研究间存在异质性。对称检验结果P＝0.01，＜0.05，认为存在发表偏倚。
结论 增强超声在脾脏良恶性占位鉴别诊断中有良好的价值。 |
| 关键词: 增强超声 脾脏 局灶性病变 Mete分析 |
| DOI： |
| 投稿时间：2020-07-10修订日期：2020-07-28 |
| 基金项目: |
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| Contrast-enhanced ultrasound in Diagnosis of Benign and Malignant Spleen Lesions：A Meta-analysis |
| Yang Jiali,Li Jiawu,Ye Guilin,Luo Yan |
| (West China Hospital,Sichuan University) |
| Abstract: |
| [Abstract] Objective The aim of this study is to evaluate the differential diagnostic value of contrast-enhanced ultrasound (CEUS) for benign and malignant spleen lesions. Materials and Methods Clinical research reports of contrast-enhanced ultrasound(CEUS) differential diagnosis of splenic benign and malignant lesions were collected from Google scholar, PubMed, Embase, VIP database, WanFang database, CNKI during the time from establishment to March 10,2020. The two researchers screened the literature and extracted relevant information respectively and use QUADAS tool to evaluate the quality of all the included literatures. The software STATA 15.1 was used for statistical analysis. Results A total of 19 literatures (776patients, 875 lesions, 515 benign lesions and 360 malignant lesions) were included. The overall sensitivity of CEUS in the differential diagnosis of benign and malignant lesions of spleen was 0.97[95% CI: 0.91,0.99], the overall specificity was 0.91[95% CI: 0.87,0.93], the overall positive likelihood ratio was 10.5[95%CI: 7.7,14.4], the overall negative likelihood ratio was 0.04[95% CI: 0.01,0.10], the overall diagnosis ratio was 274 [95% CI: 96,781], and the area under the SROC curve was 0.96[95%CI:0.94,0.97], the sensitivity Q test P < 0.01, the I2 statistic was 65.63%, indicating the heterogeneity among the studies. The results of symmetry test were P = 0.01 and < 0.05, indicating the existence of publication bias.
Conclusion Contrast-enhanced ultrasound (CEUS) is a valuable diagnostic method for benign and malignant lesions of spleen. |
| Key words: Contrast-enhanced ultrasound Splenic -lesions Meta-analysis |
