Purpose To evaluate the combination therapy effect of radiofrequency ablation (RFA) for the treatment of the great saphenous vein, stripping surgery for incompetent perforator veins and foam sclerosis treatment for shallow veins. Furthermore, to analyze the factors affecting the closure rate of the great saphenous vein trunk after radiofrequency ablation，The boundary value points of the influencing factors were obtained by ROC curve.Methods 102 cases of lower extremity varices (168 limbs) in our hospital from October 2018 to October 2019 treated with combination therapy of radiofrequency ablation, stripping surgery and foam sclerotherapy were enrolled in this survey. The follow-up of all patients was carried out by ultrasound imaging after 6 months to evaluate the treatment effect and analyze the factors related to the closure rate of RFA，and calculate its boundary point.Results All the 168 treated limbs were followed up for 6 months. CEAP was rated by the same clinician,and ultrasound was performed by the same sonographer. Results indicated that 23 limbs still required surgical intervention. Among them, 12 limbs were recanalized at the RFA site in ultrasound imaging, however, without obvious clinical symptoms; Collateral varicose veins recurrence in 2 limbs; small saphenous varicose veins appear in 4 limbs; and the dysfunction traffic veins were seen in 5 limbs. No serious complications were found after operation. Only subcutaneous soft tissue edema of four limbs were found under the monitoring with ultrasound. The success rate of combined surgery was 87%. Logistic regression analysis indicated there were no association between age, gender, CEAP grade, blood pressure, blood glucose and lower occlusion rate. However, the diameter of saphenous vein was positively correlated with recanalization rate after radiofrequency ablation (P＜0.05).The ROC curve was drawn to determine the cutoff point for diameter affecting efficacy after radiofrequency surgery was 8.5mm. Conclusions The combination therapy effect of RFA for the great saphenous vein, stripping surgery for incompetent perforator veins and foam sclerosis for shallow veins is remarkable. An important risk factor of recanalization in RFA targeted vein is the preoperative diameter of great saphenous vein. Diameter ≥8.5mm is the cutoff point for postoperative recanalization of RFA.Therefore, personalized surgical plan is essential to improve the therapeutic effect of the surgery.