Objective To explore the value of acoustic radiation force impulse (ARFI) elastography in the identification of ductal carcinoma in situ (DCIS) with infiltrating components. Methods A total of 112 patients were diagnosed with DCIS were selected from May 2016 to June 2019, divided into pure DCIS group and DCIS with infiltrating components (DCIS-I) group according to the postoperative pathological results. The result of general clinicopathologica, mammography, ultrasound and ARFI elastography were compared between two groups. Logistic regression was used to establish a mathematical model for multi-index combined diagnosis of DCIS with infiltrating components, and the diagnostic value of the each index and their combinational model was analyzed by ROC curve. Results SWV, diameter of ultrasound, pathological grade and microcalcification with tumor had significant effects on the result of diagnostic (all P<0.05). The AUC of SWV, diameter of ultrasound , pathological grade were 0.823, 0.728 and 0.710 respectively. The diagnostic sensitivity, specificity and accuracy of microcalcification with tumor were 24.2% , 86.1% and 67.9 respectively. The combined fitting equation was logit(P) =-11.205+2.535*SWV+1.995*diameter+1.466*microcalcification with tumor+1.910*pathological grade. Its AUC was 0.923, and the best diagnostic point was 0.284. The sensitivity was 87.9%, and the specificity was 96.1%. Conclusion The accuracy of the combination of SWV, diameter of ultrasound, pathological grade and microcalcification with tumor in differentiating DCIS with infiltrating components is better than better than each alone.