Radiotherapy is an essential medical method.The ionizing radiation from radiotherapy benefits human body，but causes damage to the body with varying degrees.Current radiation protection agents are limited in application due to the unaffordable price and serious side effects.In recent years,ultrasound microbubbles is an ideal carrier hold drugs and therapeutic gases.Its drug-carrying characteristics as well as the characteristics of drug delivery by blasting targeted drugs through ultrasonic irradiation，have great application potential in biomedicine.The review of several substances that can be loaded into ultrasound microbubbles for anti-radiation effects provides a basis for the development of ideal new anti-radiation drugs.