| 摘要: |
| 目的： 运用剪切波弹性成像(SWE)评估甲状腺相关性眼病眼外肌病变(Thyroid associated ophthalmopathy，TAO)中四条眼外肌厚径及平均杨氏模量值(Emean)的变化，探讨其对TAO的诊断价值。
方法： 随机收集在兰大二院内分泌科住院的TAO患者60例，根据2008年欧洲研究学会TAO分级标准将其分为两个亚组：A组(TAO水肿期)38例和B组(TAO纤维化期)22例，另选取年龄、性别相匹配的健康志愿者50例为对照组。采用高频超声测量眼外肌厚径，SWE测量眼外肌平均杨氏模量值(Emean)，以甲状腺相关性眼病分级评估结果为标准绘制接受者操作特征(ROC)曲线，确定诊断TAO的截点值。
结果： TAO组患者眼外肌厚径及Emean值均大于对照组(P<0.05)。对照组、A组、B组四条眼外肌Emean值有逐渐增高的趋势(P<0.05)，TAO亚组(A组、B组)厚径无显著性差异(P＞0.05)。ROC曲线显示，上直肌、下直肌、外直肌、内直肌Emean值诊断TAO的截点分别为9.85kPa、9.65kPa、9.85kPa、9.65kPa，曲线下面积分别为0.937、0.922、0.94、0.94；敏感性分别为86%、78%、82%、80%，特异性分别为90%、95%、95%、98.3%。
结论： SWE可通过定量评估眼外肌弹性为临床诊断甲状腺相关性眼病眼外肌病变提供参考。 |
| 关键词: 超声检查 甲状腺相关性眼病眼外肌病变 剪切波弹性成像 眼外肌 |
| DOI： |
| 投稿时间：2020-10-09修订日期：2020-11-13 |
| 基金项目: |
|
| Application of Shear Wave Elastography in Extraocular Myopathies of Thyroid-related Ophthalmopathy |
| qin qin |
| (Lanzhou University Second Hospital) |
| Abstract: |
| Objective: To use shear wave elastography (SWE) to evaluate the changes in the thickness
and diameter of the four extraocular muscles and the average Young''s modulus (Emean) in
thyroid-associated ophthalmopathy (TAO), and to explore its diagnostic value for TAO .
Methods: Randomly collected 60 TAO patients hospitalized in the Department of Endocrinology, Second Hospital of Lanzhou University, and divided them into two subgroups according to the TAO grading standard of the European Research Society in 2008: Group A (TAO edema) 38 cases and Group B (TAO) Fibrosis stage) 22 cases, and 50 healthy volunteers matching age and sex as the control group. High-frequency ultrasound was used to measure the thickness and diameter of extraocular muscles, SWE was used to measure the average Young''s modulus (Emean) of extraocular muscles, and the receiver operating characteristic (ROC) curve was drawn based on the grading assessment results of thyroid-related ophthalmopathy to determine the diagnosis of TAO Cutoff point value. Results: The thickness and Emean value of extraocular muscles in the TAO group were higher than those in the control group (P<0.05). The Emean values of the four extraocular muscles in the control group, A group, and B group gradually increased (P<0.05), and there was no significant difference in thickness and diameter of the TAO subgroups (group A, group B) (P>0.05). The ROC curve shows that the cut-off points of the superior rectus, inferior rectus, external rectus, and medial rectus Emean values for diagnosis of TAO are 9.85kPa, 9.65kPa, 9.85kPa, 9.65kPa, respectively, and the area under the curve is 0.937, 0.922, 0.94, respectively , 0.94; sensitivities were 86%, 78%, 82%, 80%, and specificities were 90%, 95%, 95%, 98.3%.Conclusion: SWE can quantitatively assess the elasticity of extraocular muscles to provide a reference for clinical diagnosis of extraocular muscle diseases in thyroid-related ophthalmopathy. |
| Key words: ultrasonography, thyroid-associated ophthalmopathy, extraocular myopathy, shear wave elastography, extraocular muscles |
