| 摘要: |
| 目的 探讨IOTA、CDFI及CA125对卵巢肿瘤良恶性的诊断价值。方法 回顾性分析2018年9月至2020年1月在哈尔滨医科大学附属第四医院妇科住院手术患者89例，均为术前超声检查确定为卵巢肿瘤者，记录超声特征、病史及血清肿瘤标志物CA125，以病理结果为“金标准”分析IOTA简单规则、CDFI分级、血清CA125指标分别诊断及三者联合诊断卵巢肿瘤的良、恶性，计算诊断的准确性、敏感性、特异性并评价诊断价值。结果 卵巢恶性肿瘤患者声像图在肿瘤形态、边界、内部回声、有无乳头状突起、RI值、血流速度、血流位置方面与良性肿瘤患者比较，差异有统计学意义（P＜0.05）。IOTA简单规则诊断准确率为74.16%；CDFI分级诊断准确率为79.78%；血清CA125诊断最佳截断值为45.25KU/L，诊断准确率为75.28%；三者联合诊断准确率为89.89%。IOTA简单规则、CDFI分级、血清CA125及三者联合应用的AUC依次为0.863、0.786、0.744、0.894，三者联合与CDFI分级、血清CA125单独应用比较，差异有统计学意义（P＜0.05）。结论 IOTA简单规则、CDFI分级、血清CA125水平均是诊断卵巢肿瘤良恶性的有效指标；IOTA简单规则具有良好的诊断价值；CDFI分级与血清CA125辅助IOTA简单规则，联合诊断能进一步提高诊断准确性及特异性。 |
| 关键词: IOTA简单规则 阴式超声 彩色多普勒超声 卵巢肿瘤 血清CA125 |
| DOI： |
| 投稿时间：2020-11-27修订日期：2020-12-30 |
| 基金项目: |
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| Diagnostic value of IOTA simple rules combined with CDFI and CA125 for ovarian tumors |
| Nian Zijing,Dong Xiaoqiu,Jiang Na,Kong Dejiao,Wang Na,Yu Ye |
| () |
| Abstract: |
| Objective To explore the differential diagnostic value of IOTA, CDFI and CA125 for benign and malignant ovarian tumors.Methods A retrospective analysis of 89 patients undergoing gynecological surgery in the Fourth Affiliated Hospital of Harbin Medical University from September 2018 to January 2020.All patients were confirmed to be ovarian tumors by preoperative ultrasound. Collecting two-dimensional ultrasound characteristics, medical history and serum Tumor marker CA125, and using pathological results as the "gold standard" to analyze IOTA simple rules, CDFI classification, serum CA125 indicators respectively, and the three combined diagnosis of benign and malignant ovarian tumors. The accuracy, sensitivity, and specificity of the diagnosis are combined Evaluate diagnostic efficacy. Results Compared with patients with benign tumors, the ultrasound images of patients with ovarian malignant tumors,including morphology, borders, internal components, presence or absence of papillary protrusions, RI, blood flow velocity, and blood flow location, had statistically significant differences (P<0.05) . The diagnostic accuracy of the simple rules of IOTA was 74.16% ; the accuracy of CDFI classification was 79.78%; the best cut-off value of serum CA125 was 45.25KU/L, and the diagnostic accuracy was 75.28%; the diagnostic accuracy rate of the combined diagnosis of the three is 89.89%. The AUC of IOTA simple rules, CDFI classification, serum CA125 and the combination of the three were 0.863, 0.786, 0.744, 0.894. Compared with the combination of the three, the CDFI classification , serum CA125 alone had statistically significant difference(P＜0.05). Conclusion IOTA simple rules, CDFI classification, and serum CA125 levels are effective indicators for diagnosing benign and malignant ovarian tumors; IOTA simple rules have good diagnostic efficiency; the combination diagnosis of IOTA simple rules, CDFI classification and serum CA125 can further improve the diagnostic accuracy and specificity. |
| Key words: IOTA simple rules Transvaginal ultrasound Color Doppler ultrasound Ovarian tumor Serum CA125 |
