| 摘要: |
| 目的；探讨超声造影参数与弹性成像应变率比值对甲状腺良恶性结节的预测价值。方法：选取136例甲状腺结节患者的临床资料进行回顾性分析,研究时间为2017年5月至2020年03月,经病理检查确诊为良性结节共102例、恶性结节共34例,均给予超声造影与弹性成像检测并获得超声造影参数及弹性成像应变率比值,采用Pearsom法分析其与血管新生基因的关系。结果：超声造影的阳性预测值、阴性预测值、敏感度、特异性、准确率均高于弹性成像,而误诊率、漏诊率均低于弹性成像(P均＜0.05)。甲状腺恶性结节的AUC、Peak低于良性结节,而Tp、弹性成像应变率比值高于良性结节(P＜0.05)；甲状腺恶性结节的MTT与良性结节齐同(P＞0.05)。超声造影的ROC曲线下面积AUC值分为(0.961,P＜0.05)。弹性成像的ROC曲线下面积AUC值分为(0.799,P＜0.05)。弹性成像应变率比值的ROC曲线下面积AUC值分为(0.995,P＜0.05),敏感度100.00%,特异性94.10%,约登指数0.941。Tp、AUC、Peak、超声造影综合参数的ROC曲线下面积AUC值为(0.915/0.978/0.972/0.988,P＜0.05),敏感度(91.20%/97.10%/100.00%/100.00%),特异性(98.00%/96.10%/90.20%/91.20%),约登指数(0.892/0.932/0.902/0.912)。结论：超声造影参数与弹性成像应变率比值均能为甲状腺良恶性结节的鉴别提供重要信息,但前者的确诊率更高。 |
| 关键词: 甲状腺 良性结节 恶性结节 超声造影 弹性成像应变率比值 血管新生基因 |
| DOI： |
| 投稿时间：2020-12-21修订日期：2021-02-03 |
| 基金项目: |
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| Difference of strain rate ratio between contrast-enhanced ultrasound and elastography in benign and malignant thyroid nodules and its relationship with angiogenesis genes |
| Wang yadong |
| () |
| Abstract: |
| Objective: To investigate the value of contrast-enhanced ultrasound parameters and elastography strain rate ratio in the differential diagnosis of benign and malignant thyroid nodules, and to analyze their relationship with angiogenesis genes. Methods: 136 patients with thyroid nodules were selected as the research objects. The study period was from May 2017 to March 2020. A total of 102 cases of benign nodules and 34 cases of malignant nodules were diagnosed by pathological examination. All patients were given contrast ultrasound and Elastography was used to detect and obtain the contrast-enhanced ultrasound parameters and the ratio of elastography strain rate, and the Pearsom method was used to analyze its relationship with angiogenesis genes. Results: The positive predictive value, negative predictive value, sensitivity, specificity, and accuracy of contrast-enhanced ultrasound were all higher than elastography, while the misdiagnosis rate and missed diagnosis rate were lower than elastography (all P<0.05).The AUC and Peak of malignant thyroid nodules are lower than that of benign nodules, while the ratio of Tp and elastography strain rate is higher than that of benign nodules (P<0.05); the MTT of malignant thyroid nodules is the same as that of benign nodules (P>0.05) .The AUC value of the area under the ROC curve of contrast-enhanced ultrasound was (0.961, P＜0.05). The AUC value of the area under the ROC curve of elastography was divided into (0.799, P＜0.05).The AUC value of the area under the ROC curve of the elastography strain rate ratio is (0.995, P<0.05), the sensitivity is 100.00%, the specificity is 94.10%, and the Youden index is 0.941.The area under the ROC curve of the comprehensive parameters of Tp, AUC, Peak, and contrast-enhanced ultrasound AUC value is (0.915/0.978/0.972/0.988, P＜0.05), sensitivity (91.20%/97.10%/100.00%/100.00%), specificity(98.00%/96.10%/90.20%/91.20%),Youden Index (0.892/0.932/0.902/0.912).Conclusion: The decrease of contrast-enhanced parameters of malignant thyroid nodules and the increase of elastography strain rate ratio are directly related to the exuberance of tumor angiogenesis genes, which can be used as reliable indicators for judging the malignancy of thyroid nodules. |
| Key words: thyroid benign nodules malignant nodules contrast-enhanced ultrasound elastography strain rate ratio angiogenesis genes |
