[Objectives] To evaluate the application of the VTIQ and to analysisSthe correlation among SWV,CSA and MNFR,to evaluate the diagnostic value of the VTIQ in the diagnosis of CTS. [Methods] The study included 40 patients (67 wrists) and 20 healthy volunteers (40wrists). The median nerve(MN)CSA, SWV and MNFR were studied. The differences between CTS patients and controls were studied by independent sampleST-test.ROC analysis was performed. The correlations were analyzed among SWV, CSA and MNFR. [Results] There was significant differences of the MN SWV, CSA between CTS group and healthy control (P<0.01). The cut-off value of SWV for diagnosing CTS was 3.30m/s, and the sensitivity, specificity and accuracy of SWV were better than that of CSA. The combined diagnostic performance sensitivity and accuracy of the two indexes is higher than that of the single index. There is a positive correlations among the SWV,CSA and MNFR.[Conclusions] The changes of CSA and SWV reflected the thickening of MN morphology and the hardening of histology in CTS patients.VTIQ technique was in good agreement with MRI results.The application of VTIQ in the diagnosis of CTS has a good practical value under the premise of following the clinical guidelines and recommendations of elastic imaging.The combined application of VTIQ technology and CSA can reduce the rate of missed diagnosis and provide more abundant imaging diagnostic basis for patients with correct standardized treatment of CTS.