| 摘要: |
| 目的：探讨超声引导下剪切波弹性成像评估A型内毒素注射治疗脑性瘫痪患儿的效果。方法：回顾性分析2016年5月至2019年6月诊治的86例脑性瘫痪患儿临床资料，其中，86例脑性瘫痪患儿设立为观察组，按照治疗方法的不同分为B组（予以康复训练）与A组（在康复训练的基础上予以超声引导下BTX-A注射治疗），各43例，另选取43例正常儿童作为健康对照组；且评估Emean值（内侧腓肠肌、比目鱼肌、半膜肌）、MAS评分、CMFM-88评分、PROM，分析Emean值与MAS的相关性，以及观察Emean值的AUC值。结果：观察组内侧腓肠肌、比目鱼肌、半膜肌的Emean值显著高于健康对照组（P均＜0.05）。治疗后1、6个月后，A组的MAS评分、PROM、Emean值（内侧腓肠肌、比目鱼肌、半膜肌）低于B组，而CMFM-88评分高于B组（P均＜0.05）。Pearson 相关性显示，内侧腓肠肌、比目鱼肌、半膜肌的Emean值与MAS评分呈正相关（P均＜0.05）。ROC曲线分析显示，内侧腓肠肌、比目鱼肌、半膜肌的Emean值曲线下面积AUC值为（0.746/0.732/0.771，敏感度90.70/95.30/95.30，特异度59.30/57.00/58.10，P＜0.05）。结论：在超声引导下行BTX-A注射治疗效果显著，能在改善患儿肌肉痉挛的同时，降低肌肉组织硬度。 |
| 关键词: 超声 BTX-A注射 脑性瘫痪 MAS评分 SWE参数 |
| DOI： |
| 投稿时间：2020-12-29修订日期：2021-01-12 |
| 基金项目: |
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| The effect of ultrasound-guided BTX-A injection in the treatment of cerebral palsy on the MAS score of children and its relationship with SWE parameters |
| He Wei,Lu Xiaofei,Ge Zhicheng |
| () |
| Abstract: |
| Objective: To investigate the effect of ultrasound-guided BTX-A injection in the treatment of cerebral palsy on children""s MAS score and analyze its relationship with SWE parameters. Methods: A retrospective analysis of the clinical data of 86 children with cerebral palsy diagnosed and treated from May 2016 to June 2019. Among them, 86 children with cerebral palsy were set up as the observation group and divided into group B according to different treatment methods ( Rehabilitation training) and group A (BTX-A injection therapy under ultrasound guidance based on rehabilitation training), 43 cases in each, 43 normal children were selected as the healthy control group; and Emean value (medial gastrocnemius, soleus muscle) , Semimembranous muscle), MAS score, CMFM-88 score, PROM, analyze the correlation between Emean value and MAS, and observe the AUC value of Emean value. Results: The Emean values of the medial gastrocnemius, soleus, and semimembrane muscle of the observation group were significantly higher than those of the healthy control group (all P<0.05). After 1 and 6 months after treatment, the MAS score, PROM and Emean values (medial gastrocnemius, soleus, semimembrane) of group A were lower than those of group B, while CMFM-88 score was higher than that of group B (all P＜0.05) . Pearson correlation showed that the Emean value of medial gastrocnemius, soleus, and semimembrane was positively correlated with MAS score (all P<0.05). ROC curve analysis showed that the area under the curve of the Emean value of the medial gastrocnemius, soleus, and semimembrane muscles was AUC (0.746/0.732/0.771, sensitivity 90.70/95.30/95.30, specificity 59.30/57.00/58.10, P<0.05) . Conclusion: The ultrasound-guided BTX-A injection has a significant therapeutic effect, which can reduce the stiffness of the muscle tissue while improving muscle spasm in children. |
| Key words: ultrasound BTX-A injection cerebral palsy MAS score SWE parameters |
