| 摘要: |
| 目的 采用 Meta 分析方法评价肺脏超声对结缔组织病相关间质性肺疾病的诊断价值。方法 检索PubMed、Embase、Cochrane library、CBM、CNKI 、维普和万方数据库,检索时间为建库至 2020年10月,由2名研究员依据纳入和排除标准,查找相关文献,用QUADAS-2表对文献行质量评价,用RevMan5.2、Stata12.0和Meta-Disc 1.4 软件进行分析,计算合并的敏感度、特异度、阳性似然比、阴性似然比和诊断优势比,制作汇总受试者工作特征曲线(SROC)并计算曲线下面积(AUC),进行异质性检验、敏感性分析和回归分析,用Deek’s 检验分析文献发表偏倚。结果 共纳入11篇文献进一步分析,中文文献3篇,英文文献8篇,共599例患者。Meta分析显示各研究结果间存在异质性,采用随机效应模型分析,合并敏感度0.92 (95%CI：0.89～0.95),合并特异度0.73(95%CI：0.67～0.78),合并阳性似然比4.31(95%CI:2.39～7.77),合并阴性似然比0.08(95%CI:0.04～0.18),合并诊断优势比53.11(95%CI:27.39～102.97),SROC曲线下面积为0.94,Q*0.8796,未见明显发表偏倚。结论：Meta分析示肺部超声对结缔组织病相关性间质性肺疾病有较高的诊断价值。 |
| 关键词: 超声 间质性肺疾病 Meta分析 |
| DOI： |
| 投稿时间：2021-01-25修订日期：2021-01-25 |
| 基金项目: |
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| Diagnostic value of lung ultrasound for interstitial lung disease related to connective tissue disease：A Meta-analysis |
| GONG Haiyan,TANG Shiqi,YANG Yating,WANG Ping |
| (Department of Ultrasound,the Third Affiliated Hospital of Southern Medical University) |
| Abstract: |
| Objective Use Meta analysis method to evaluate the diagnostic value of lung ultrasound for interstitial lung disease related to connective tissue disease. Methods PubMed, Embase,Cochrane library, CBM, CNKI, VIP and Wanfang databases were searched during time from establishment to October 2020. Two researchers according to the inclusion and exclusion criteria of diagnostic tests found relevant literature and used QUADAS2 to evaluate the quality of the literature and used RevMan5.2、Stata12.0 and Meta-Disc 1.4 software for statistical analysis and calculated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio,drawed the summarized receiver operator characteristic (SROC) curve and calculated area under the curve (AUC), conducted heterogeneity test, sensitivity analysis and regression analysis, and used Deek’s test to analyze publication bias. Results A total of 11 articles were included, including 3 Chinese articles and 8 English articles, with a total of 599 patients. Meta analysis showed heterogeneity among studies and used random effects model, The pooled sensitivity was 0.92 (95%CI: 0.89~0.95), the pooled specificity was 0.73 (95%CI: 0.67~0.78),the pooled positive The likelihood ratio was 4.31 (95%CI: 2.39~7.77), the pooled negative likelihood ratio was 0.08 (95%CI: 0.04~0.18), the pooled diagnostic odds ratio was 53.11 (95%CI: 27.39~102.97), the area under the SROC curve was 0.94, Q* was 0.8796, there was no obvious publication bias. Conclusion: Meta analysis shows that lung ultrasound has a high diagnostic value for connective tissue disease-related interstitial lung disease. |
| Key words: Ultrasound Interstitial lung disease Meta-analysis |
