| 摘要: |
| 目的： 探讨甲状腺乳头状癌（PTC）的超声弹性评分、应变率比值(SR)与程序性细胞死亡基因4（PDCD4）、表没食子儿茶素没食子酸酯（EGCG）、Xklp2靶蛋白（TPX2）表达的相关性。方法：选择2018年1月-2020年10月于本院就诊的86例甲状腺结节患者的临床资料，所有患者均为单发甲状腺结节，根据病理结果分为PTC组（49例，49个甲状腺结节）与良性肿瘤组（37例，37个甲状腺结节），所有患者行超声弹性成像检查、组织活检。比较PTC组与良性肿瘤组的弹性评分、SR的差异，并分析PTC患者的弹性评分、SR值与PDCD4、EGCG、TPX2的相关性。结果：PTC组的弹性评分、SR值显著高于良性肿瘤组（P<0.05）。PTC组结节的PDCD4、EGCG表达显著低于良性肿瘤组（P<0.05），而TPX2表达则显著高于良性肿瘤组（P<0.05）。PTC患者的弹性评分、SR值与PDCD4、EGCG表达成负相关（P<0.05），而与TPX2的表达成正相关（P<0.05）。结论：PTC与甲状腺良性肿瘤的弹性评分和SR值有显著差异，PTC的弹性评分和SR值与PDCD4、EGCG的表达呈负相关，与TPX2的表达呈正相关，进一步说明超声弹性成像能准确地鉴别诊断甲状腺结节的良恶性，可在一定程度上可反映PTC的恶性生物学行为，具有较高的临床应用价值。 |
| 关键词: 甲状腺乳头状癌 弹性成像 程序性细胞死亡基因4 表没食子儿茶素没食子酸酯 Xklp2靶蛋白 相关性 |
| DOI： |
| 投稿时间：2021-01-28修订日期：2021-02-20 |
| 基金项目:2016年安徽省卫生和计划生育委员会科研计划项目（2016KQ239） |
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| Correlation between ultrasonic elasticity score,strain rate ratio and expression of PDCD4, EGCG and TPX2 in papillary thyroid carcinoma |
| Zheng Hui |
| () |
| Abstract: |
| Objective: To explore the correlation between ultrasonic elasticity score,strain rate ratio and expression of PDCD4, EGCG and TPX2 in papillary thyroid carcinoma.Methods: The clinical data of 86 patients with thyroid nodules who were treated in our hospital from January 2018 to October 2020 were selected. All patients were single thyroid nodules. According to the pathological results, they were divided into PTC group （106 cases, 106 thyroid nodules） Section） and benign tumor group （80 cases, 80 thyroid nodules）, all patients underwent ultrasound elastography and tissue biopsy. The differences in elasticity score and strain rate ratio （SR） between the PTC group and the benign tumor group were compared, and the correlation between the elasticity score and SR value of PTC patients and PDCD4, EGCG, TPX2 was analyzed.Results: The elasticity score and SR value of the PTC group were significantly higher than those of the benign tumor group （P<0.05）. The expression of PDCD4 and EGCG in the nodules of the PTC group was significantly lower than that of the benign tumor group （P<0.05）, while the expression of TPX2 was significantly higher than that of the benign tumor group （P<0.05）. The elasticity score and SR value of PTC patients are negatively correlated with the expression of PDCD4 and EGCG （P<0.05）, and positively correlated with the expression of TPX2 （P<0.05）.Conclusion: The elasticity score and SR value of PTC and benign thyroid tumors are significantly different. The elasticity score and SR value of PTC are negatively correlated with the expression of PDCD4 and EGCG, and positively correlated with the expression of TPX2, which further shows that ultrasound elastography can accurately differentiate and diagnose thyroid The benign and malignant nodules can reflect the malignant biological behavior of PTC to a certain extent, and have high clinical application value. |
| Key words: Papillary thyroid carcinoma programmed cell death gene 4 epigallocatechin gallate Xklp2 target protein Correlation |
