Objective: To explore the predictive value of contrast-enhanced ultrasound (CEUS) time-intensity curve (TIC) and CT angiography (CTA) for recurrence of ischemic stroke (IS). Methods: A total of 95 patients with ischemic stroke admitted to our hospital from January 2018 to January 2020 were selected, and all patients were examined by CEUS and CTA. The patient was followed up for 1 year after discharge. According to the follow-up results, they were divided into recurrence group and non-recurrence group for comparison, and ROC curve was used to evaluate the predictive value. Results: The proportion of age ≥ 65 years in the recurrence group was significantly higher than that of the non-recurring group, and the proportion of combined hypertension was significantly higher than that of the non-recurring group (P<0.05); the degree of vascular stenosis in the non-recurring group was significantly better than that of the recurring group (P<0.05) The time to peak (TTP) of the recurrence group was significantly shorter than that of the non-recurring group, and the peak intensity (PI) and area under the curve (AUCTC) were significantly higher than those of the non-recurring group (P<0.05). Logistic regression analysis showed that the TTP was short and the blood vessel Stenosis and high AUCTC are independent risk factors for IS recurrence; ROC curve analysis shows that the AUC of AUCTC, CTA, and the two combined predictions for IS recurrence are 0.694, 0.906, and 0.951, respectively, and their sensitivity and specificity are 81.8% and 52.9%, respectively , 81.8%, 90.2%, 88.6%, 100%. Conclusion: The value of CEUS-TIC combined with CTA in predicting IS recurrence is higher than its independent prediction. Vascular stenosis and unstable plaque are risk factors for IS recurrence.