Objective To evaluate carotid plaque stability in patients with coronary artery disease, we analyze the relation between carotid atherosclerotic plaque stability and acute coronary syndrome in double-modal by using SWE (shear wave elastography) and CEUS (contrast-enhanced ultrasound). Methods A total of 88 patients with CHD were enrolled after January 2019. Patients were devided into Un-ST-elevation acute coronary syndrome group (ACS n=45) and stable coronary heart disease (SCHD n=43). Plaque hardness was measured with E-modulus in SWE and density maximum in CEUS. Blood biochemical tests were carried out. Results Logistic regression analysis showed that carotid atherosclerotic plaque enhancement density is an independent risk factor for ACS(OR=2.853，95％CI 0.161-7.091，P=0.027). There were significant differences in mean E-modulus in SWE and density maximum in CEUS between ACS group and SCHD group（P＜0.05）. The stability of carotid plaques was significantly correlated with the severity of coronary artery lesions. Conclusions Quantitative analysis of carotid artery plaques by SWE combined with CEUS are helpful to predict the severity of coronary artery lesions.