Objective: To explore the diagnostic efficacy of High-resolution ultrasonography (HRU) combined with Fasting Blood Glucose (FBG) and Glycated hemoglobin (HbAlc) for early diabetic Median nerve (MN) damage. Methods: The clinical data of 64 early diabetic patients admitted to our hospital were selected and divided into 30 diabetic peripheral neuropathy (DPN) group (DPN group) according to the results of Neural electrophysiological test (NET). 34 cases of diabetic non-peripheral neuropathy group (non-DPN group), another 32 cases of healthy people during physical examination during the same period were selected as the control group. NET and HRU examinations were performed on all patients"" MN, and FBG and HbA1c levels were detected in parallel, and the HRU characteristics of MN and the differences in FBG and HbA1c levels between the groups were compared. Receiver operating characteristic (ROC) was used. Curve analysis of its diagnostic efficacy for MN injury.Results: The differences between DPN group and non-DPN group and control group were statistically significant (P<0.05) in the HRU sonographic characteristics and measurement values of MN, as well as the patient""s FBG and HbA1c levels (P<0.05). The area under the ROC curve of HRU combined with FBG and Hb1Ac levels to diagnose MN injury in early diabetic patients was the largest (P<0.05), and the sensitivity and specificity were the highest. Conclusion: HRU, FBG and Hb1Ac levels are helpful to the diagnosis of type 2 diabetic peripheral neuropathy, and HRU combined with FBG and Hb1Ac levels can help improve the diagnostic efficiency of early diabetic MN damage, and can further guide the choice of clinical treatment options.