Objective: To explore the application value of placental elastic modulus combined with miR-10b in predicting pre-eclampsia. Methods: The clinical data of 120 pregnant women with suspected preeclampsia were selected for retrospective analysis. The selection time was from February 2018 to March 2020. After the gold standard (24h urine protein quantitative) examination, 35 cases were diagnosed as preeclampsia. (Observation group) and 85 normal pregnant women (control group), and were tested with SWE technology and serum miR-10b. The Young"s modulus and miR-10b expression of each part of the placenta of the two groups were compared to evaluate the placental Young"s modulus. The value, miR-10b, the AUC value, sensitivity, specificity, and Youden index of the two combined diagnosis of PE, analysis of the correlation between placental Young"s modulus and miR-10b. Results: The Young"s modulus of the placenta at the center and edge of the observation group was higher than that of the control group, while the expression of miR-10b was lower than that of the control group (P<0.05). ROC curve analysis showed that the Young"s modulus at the center, the Young"s modulus at the edge, miR-10b, and the combined AUC of the two were (0.879, 0.818, 0.906, 0.997, P<0.05), and the sensitivity was respectively 82.90%, 71.40%, 88.60%, 100.00%, the specificity is 89.40%, 100.00%, 78.80%, 98.80%, and the Youden index are 0.723, 0.714, 0.674, 0.988, respectively. The Pearson correlation showed that the Young"s modulus of the placenta at the center and the edge was negatively correlated with miR10b (r=-0.289/-0.281, P<0.05). Conclusion: Placental elastic modulus combined with miR-10b has high clinical value for predicting pre-eclampsia. The two complement each other and can provide important reference information for clinical diagnosis.