| 摘要: |
| 目的：探讨胎盘弹性模量联合miR-10b在预测先兆子痫的应用价值。方法：选取120例疑似先兆子痫孕妇的临床资料进行回顾性分析,选取时间为2018年2月至2020年3月,经金标准(24h尿蛋白定量)检查,确诊为子痫前期共35例(观察组)、正常孕妇85例(对照组),且予以SWE技术和血清miR-10b检测,对比两组胎盘各部位的杨氏模量值、miR-10b表达量,评估胎盘杨氏模量值、miR-10b、两项联合诊断PE的AUC值、敏感度、特异度、约登指数,分析胎盘杨氏模量值与miR-10b相关性分析相关性。结果：观察组中央部位、边缘部位的胎盘杨氏模量值高于对照组,而miR-10b表达量低于对照组(P＜0.05)。ROC曲线分析显示,中央部位杨氏模量值、边缘部位杨氏模量值、miR-10b、两项联合的AUC分别为(0.879、0.818、0.906、0.997,P＜0.05),敏感度分别为82.90%、71.40%、88.60%、100.00%,特异度分别为89.40%、100.00%、78.80%、98.80%,约登指数分别为0.723、0.714、0.674、0.988。Pearson相关性显示,中央部位、边缘部位的胎盘杨氏模量值与miR10b呈负相关(r=-0.289/-0.281,P＜0.05)。 结论：胎盘弹性模量联合miR-10b用于预测先兆子痫具有较高的临床价值,两者相互弥补,能为临床诊断提供重要参考信息。 |
| 关键词: 胎盘弹性模量 miR-10b 预测 先兆子痫 |
| DOI： |
| 投稿时间：2021-03-31修订日期：2021-05-21 |
| 基金项目: |
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| Application of placental elastic modulus combined with miR-10b in predicting preeclampsia |
| Yao Lu,Ding Yanyan,Ma Hongyun,Bai Rong,Ma Zongli |
| () |
| Abstract: |
| Objective: To explore the application value of placental elastic modulus combined with miR-10b in predicting pre-eclampsia. Methods: The clinical data of 120 pregnant women with suspected preeclampsia were selected for retrospective analysis. The selection time was from February 2018 to March 2020. After the gold standard (24h urine protein quantitative) examination, 35 cases were diagnosed as preeclampsia. (Observation group) and 85 normal pregnant women (control group), and were tested with SWE technology and serum miR-10b. The Young"s modulus and miR-10b expression of each part of the placenta of the two groups were compared to evaluate the placental Young"s modulus. The value, miR-10b, the AUC value, sensitivity, specificity, and Youden index of the two combined diagnosis of PE, analysis of the correlation between placental Young"s modulus and miR-10b. Results: The Young"s modulus of the placenta at the center and edge of the observation group was higher than that of the control group, while the expression of miR-10b was lower than that of the control group (P<0.05). ROC curve analysis showed that the Young"s modulus at the center, the Young"s modulus at the edge, miR-10b, and the combined AUC of the two were (0.879, 0.818, 0.906, 0.997, P<0.05), and the sensitivity was respectively 82.90%, 71.40%, 88.60%, 100.00%, the specificity is 89.40%, 100.00%, 78.80%, 98.80%, and the Youden index are 0.723, 0.714, 0.674, 0.988, respectively. The Pearson correlation showed that the Young"s modulus of the placenta at the center and the edge was negatively correlated with miR10b (r=-0.289/-0.281, P<0.05). Conclusion: Placental elastic modulus combined with miR-10b has high clinical value for predicting pre-eclampsia. The two complement each other and can provide important reference information for clinical diagnosis. |
| Key words: placental elastic modulus miR-10b prediction preeclampsia |
