| 摘要: |
| 目的：探讨超声造影（CEUS）结合剪切波弹性成像（SWE）对肝硬化背景下肝实质内良恶性结节诊断价值研究。方法：选择2019年1月至2021年2月本院收治的92例肝硬化合并肝实质内结节患者的临床资料，根据病理结果分为恶性组（52例）和良性组（40例）。所有患者术前均行CEUS、SWE检查，比较两组之间各参数的差异，并分析CEUS、SWE单独或联合诊断恶性结节的价值。结果：肝实质内结节动脉期、门脉期及延迟期的CEUS特征在恶性组与良性组之间差异具有统计学意义（P<0.05），其中恶性组肝实质内结节大多呈“快进快出”表现，而良性组大多呈“慢进慢出”表现。恶性组肝实质内结节的杨氏模量最大值（Emax）为（42.36±5.37）kPa，而良性组为（36.49±6.12）kPa，且两组之间比较差异具有统计学意义（P<0.05）。与CEUS、SWE单独诊断相比较，CEUS结合SWE联合诊断恶性结节的准确性、敏感度、特异度、阳性预测值、阴性预测值最高，且差异具有统计学意义（P<0.05）。结论：CEUS结合SWE有助于提高对肝硬化背景下肝实质内良恶性的鉴别诊断价值，对临床治疗方案的选择有一定指导意义。 |
| 关键词: 超声造影 剪切波弹性成像 肝硬化 结节 杨氏模量 |
| DOI： |
| 投稿时间：2021-04-28修订日期：2021-04-28 |
| 基金项目: |
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| Value of contrast-enhanced ultrasound combined with shear wave elastography in the diagnosis of benign and malignant nodules in liver parenchyma under the background of cirrhosis |
| Pan Xi |
| () |
| Abstract: |
| Objective: To explore the diagnostic value of contrast-enhanced ultrasound combined with shear wave elastography in the diagnosis of benign and malignant nodules in the liver parenchyma under the background of liver cirrhosis. Methods: The clinical data of 92 patients with liver cirrhosis and intrahepatic nodules in our hospital from January 2019 to February 2021 were selected and divided into malignant group (52 cases) and benign group (40 cases) based on the pathological results. All patients underwent CEUS and SWE examinations before surgery to compare the differences in parameters between the two groups, and analyze the value of CEUS and SWE alone or in combination in the diagnosis of malignant nodules. Results: The CEUS characteristics of intrahepatic nodules in the arterial phase, portal phase, and delayed phase were statistically different between the malignant group and the benign group (P<0.05), and most of the intrahepatic nodules in the malignant group showed "fast-forwarding fast" The benign group mostly showed the performance of "slow in and slow out". The maximum Young""s modulus (Emax) of nodules in the liver parenchyma in the malignant group was (42.36±5.37) kPa, while that of the benign group was (36.49±6.12) kPa, and the difference between the two groups was statistically significant (P< 0.05). Compared with the separate diagnosis of CEUS and SWE, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of combined CEUS and SWE in the diagnosis of malignant nodules were the highest, and the difference was statistically significant (P<0.05). Conclusion: CEUS combined with SWE can help to improve the differential diagnosis value of benign and malignant liver parenchyma under the background of liver cirrhosis, and has certain guiding significance for the selection of clinical treatment plan. |
| Key words: Contrast-enhanced Ultrasound Shear Wave Elastography Liver Cirrhosis Nodules Young""s Modulus |
